literature

SARS_CoV_2 mutation literature information.

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants.

PMID: 34966387 2021 Frontiers in immunology

Introduction: Most class I mAbs were largely disrupted by the K417N/T mutation and class II mAbs by the E484K mutation.

Introduction: The Beta and Gamma variants each has three mutation sites in common within the RBD region:K417N/T, E484K, and N501Y:which change their antigenic profiles.

Introduction: Through crystal and electron cryo-microscopy (cryo-EM) structure analyses, P36-5D2 was found to target a conserved epitope on the RBD of the spike protein, bypassing the three key mutations (K417N, E484K, and N501Y) responsible for immune escape from many potent neutralizing mAbs.

SARS-CoV-2 Variants: Mutations and Effective Changes.

PMID: 34975266 2021 Biotechnology and bioprocess engineering

Abstract: Certain mutations (D614G, E484K, N501Y, K417N, L452R and P681R) have appeared across several different strains, often accompanied by others that may be complementary working together to confer increased infectivity, fitness, or resistance to neutralization.

SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster.

PMID: 34981057 2021 bioRxiv

Introduction: The predominant strain of Omicron has mutations in the spike gene encoding 15 amino acid changes in the receptor binding domain (RBD) of the spike surface protein (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, and Y505H).

Analysis of Clinical Characteristics and Virus Strains Variation of Patients Infected With SARS-CoV-2 in Jiangsu Province-A Retrospective Study.

PMID: 35004593 2021 Frontiers in public health

Table: K417N

Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic Review.

PMID: 35008446 2021 International journal of molecular sciences

Introduction: Similarly, K417N, E484K, and N501Y mutations were selected when pseudotyped SARS-CoV-2 was cultured in the presence of vaccine-elicited mAbs.

The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants.

PMID: 35047474 2021 Frontiers in public health

Result: Furthermore, for Cq over 25 no SARS-CoV-2 variant (K417N/T, E484K, and N501Y) sample was detected by RAT.

Result: Interestingly, from the three SARS-CoV-2 (K417N/T, E484K, and N501Y) positive samples for RAT, two of them presented a band of low intensity (Table 2) compared to SARS-CoV-2 samples with no mutations identified, which present a high-intensity band in the range 20>=Cq <25 (Table 1).

Result: When we evaluated these NPSs containing SARS-CoV-2 variants, we observed that the sensitivity of RAT decreased in the variants that carry K417N/T and E484K amino acid substitutions, even in samples with the lowest ranges of Cq (20 <= Cq <25).

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.

PMID: 35126106 2021 Frontiers in pharmacology

Abstract: Furthermore, fluoxetine remained effective against pseudoviruses with common receptor binding domain mutations, N501Y, K417N, and E484K, as well as B.1.1.7 (alpha), B.1.351 (beta), and B.1.617.2 (delta) variants of SARS-CoV-2.

Introduction: A common RBD mutation, N501Y, is shared by alpha, beta, and gamma, while K417N and E484K are found in beta and gamma.

Introduction: Moreover, infection by pseudotyped viruses carrying N501Y, K417N, or E484K single point mutations or triple mutation (N501Y/K417N/

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

PMID: 35095827 2021 Frontiers in microbiology

Table: p.Lys417Asn

Discussion: Some globally rare (~1% or less) spike substitutions in the RBD were identified, namely R346S, K417N, and N440K.

Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies.

PMID: 35140714 2021 Frontiers in immunology

Result: Among 15 substituted amino acids, K417N and Y505H exhibited a slight reduction in binding energy due to the breakage of salt bridges between K417 of the RBD and D30 of ACE2; nonetheless, this breakage was compensated by the salt bridge between E35 of ACE2 and Q493K substitution in RBDOmic ( Figure 2C , right panel).

Result: In addition, energy perturbation per amino acid could confirm that the four amino acids, i.e., <

Discussion: N440K and K444Q can escape against REGN10987, while K417N, N460T, and A475V can successfully escape against LY-CoV016 antibody (AbCellera), currently approved by the FDA for COVID-19 therapy.

Molecular recognition of SARS-CoV-2 spike glycoprotein: quantum chemical hot spot and epitope analyses.

PMID: 35355624 2021 Chemical science

Result: Currently, the highly transmissible variants of the United Kingdom (N501Y) and South Africa (N501Y, E484K, and K417N) are prevalent in various regions.

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