Introduction: Most class I mAbs were largely disrupted by the K417N/T mutation and class II mAbs by the E484K mutation.
Introduction: The Beta and Gamma variants each has three mutation sites in common within the RBD region:K417N/T, E484K, and N501Y:which change their antigenic profiles.
Introduction: Through crystal and electron cryo-microscopy (cryo-EM) structure analyses, P36-5D2 was found to target a conserved epitope on the RBD of the spike protein, bypassing the three key mutations (K417N, E484K, and N501Y) responsible for immune escape from many potent neutralizing mAbs.
SARS-CoV-2 Variants: Mutations and Effective Changes.
PMID: 34975266
2021
Biotechnology and bioprocess engineering
Abstract: Certain mutations (D614G, E484K, N501Y, K417N, L452R and P681R) have appeared across several different strains, often accompanied by others that may be complementary working together to confer increased infectivity, fitness, or resistance to neutralization.
SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster.
Introduction: The predominant strain of Omicron has mutations in the spike gene encoding 15 amino acid changes in the receptor binding domain (RBD) of the spike surface protein (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, and Y505H).
Analysis of Clinical Characteristics and Virus Strains Variation of Patients Infected With SARS-CoV-2 in Jiangsu Province-A Retrospective Study.
Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic Review.
PMID: 35008446
2021
International journal of molecular sciences
Introduction: Similarly, K417N, E484K, and N501Y mutations were selected when pseudotyped SARS-CoV-2 was cultured in the presence of vaccine-elicited mAbs.
Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data.
Result: Furthermore, for Cq over 25 no SARS-CoV-2 variant (K417N/T, E484K, and N501Y) sample was detected by RAT.
Result: Interestingly, from the three SARS-CoV-2 (K417N/T, E484K, and N501Y) positive samples f
Figure: By contrast, in the other 15 positive samples we identified the SARS-CoV-2 variants K417N/T, E484K, and N501Y (gray arrows) (Group 2).
Figure: RAT detection of SARS-CoV-2 variants which contain K417N/T, E484K, and N501Y mutations, from RT-qPCR positive samples with Cq value between 20>=Cq <25, 25>=Cq <30, 30>=Cq <35.
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
Abstract: Furthermore, fluoxetine remained effective against pseudoviruses with common receptor binding domain mutations, N501Y, K417N, and E484K, as well as B.1.1.7 (alpha), B.1.351 (beta), and B.1.617.2 (delta) variants of SARS-CoV-2.
Introduction: A common RBD mutation, N501Y, is shared by alpha, beta, and gamma, while K417N and E484K are found in beta and gamma.
Introduction: Moreover, infection by pseudotyped viruses carrying N501Y, K417N, or E484K single point mutations or triple mutation (N501Y/K417N/
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
Result: Among 15 substituted amino acids, K417N and Y505H exhibited a slight reduction in binding energy due to the breakage of salt bridges between K417 of the RBD and D30 of ACE2; nonetheless, this breakage was compensated by the salt bridge between E35 of ACE2 and Q493K substitution in RBDOmic ( Figure 2C , right panel).
Result: In addition, energy perturbation per amino acid could confirm that the four amino acids, i.e., <
Discussion: N440K and K444Q can escape against REGN10987, while K417N, N460T, and A475V can successfully escape against LY-CoV016 antibody (AbCellera), currently approved by the FDA for COVID-19 therapy.
Molecular recognition of SARS-CoV-2 spike glycoprotein: quantum chemical hot spot and epitope analyses.
Result: Currently, the highly transmissible variants of the United Kingdom (N501Y) and South Africa (N501Y, E484K, and K417N) are prevalent in various regions.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in immunology
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