Result: Further, an exceptional mutation was present at A222V among Delta, and K417N among Delta AY.1 variants.
Result: Two mutations in Spike (K417N and W258L) were exclusively present in the Delta Plus variant.
Result: We also identified 8 substitution mutants in the SARS-CoV-2, K417N, G446V, L452R, S477N, T478K, E484Q, F490S, and A522V in the RNA binding domain (RBD) of S1 subunit of Spike protein.
Table: K417N
Thermodynamics and kinetics in antibody resistance of the 501Y.V2 SARS-CoV-2 variant.
Abstract: Three substitutions in the RBD including K417N, E484K, and N501Y alter the free energy landscape, binding pose, binding free energy, binding kinetics, hydrogen bonding, nonbonded contacts, and unbinding pathway of RBD + NAb complexes.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in medicine
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