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 SARS_CoV_2 mutation literature information.


  Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regions.
 PMID: 35258772       2022       GeroScience
Introduction: V445E and K444 Q/R/N in the RBD and K150 T/Q/R/E, and N148S in NTD may be responsible for antibody escape.


  A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants.
 PMID: 34607456       2021       mBio
Abstract: As seen with some of the natural VOC, the neutralization potencies of COVID-19 convalescent-phase sera were reduced by 4- to 16-fold against rVSV-SARS2 bearing Y145D, K150E, or W152R spike mutations.
Result: For the NTD MAb (ADI-56479), rVSV-SARS2 neutralization-escape mutations mapped to residues 145 (Y145D), 150 (K150E), and 152 (W152R) in the NTD, and each one of these mutations individually afforded an ~1,000-fold increase in the neutralization IC50 values.
Result: Specifically, the sera showed a drop of 3.5-fold (Y145D) to 16-fold (K150E and W152R) in their neutralization I



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