literature

SARS_CoV_2 mutation literature information.

A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil.

PMID: 33919314 2021 Viruses

Introduction: The VOC P.1, first described in January 2021, displayed an unusual number of lineage-defining mutations in the S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) and its emergence was associated with a second COVID-19 epidemic wave in the Amazonas state.

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.

PMID: 33925854 2021 Microorganisms

Result: The BR-VOC is highly mutated in the S-gene resulting in 12 aa substitutions in the S-protein including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.

Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein.

PMID: 33991677 2021 Clinical microbiology and infection

Abstract: RESULTS: We identified that SARS-CoV-2 genomes from four patients diagnosed in our institute harboured a new set of amino acid substitutions including L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V +- Q677H.

Result: These mutations include aa substitution N501Y, associated with aa substitutions L18F, L452R, A653V, H655Y, D796Y, and G1219V, and a synonymous mutation at nucleotide position 22,468 [in reference to NC_045512.2); Figures 1 a, 1b]; an eighth

E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

PMID: 34044192 2021 Infection, genetics and evolution

Table: H655Y

Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics.

PMID: 34064904 2021 Viruses

Discussion: Although this points out to a rather different effect of T307I in comparison with other reported mutations in the gear domain, it is possible that the loss of core compactness caused by A653V and I692V, and the change in hydrophobicity induced by H655Y could have similar dynamic effects as T307I.

Discussion: Mutation H655Y alters the hydrophobicity of an exposed residue, with a less evident effect.

Discussion: The B1.525 variant harbors a Q677H mutation, the variant B1.1.7 reported in the United Kingdom carries A570D and P681H mutations, the P1 variant from Brazil shows the H655Y mutation, and the recently reported B.1.61

SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection.

PMID: 34109031 2021 Annals of medicine and surgery (2012)

Introduction: These mutations are L18F, T20N, P26S, D138Y, R190S, D614G H655Y, T1027I, and V1176F.

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Table: H655Y

Proliferation of SARS-CoV-2 B.1.1.7 Variant in Pakistan-A Short Surveillance Account.

PMID: 34136461 2021 Frontiers in public health

Discussion: Previously, H655Y (655Histidine > Tyrosine) amino acid change has been shown to confer escape from monoclonal antibodies in cell culture systems.

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.

PMID: 34166623 2021 Immunity

Method: The variant P.1 (GISAID: EPI_ISL_792681) was constructed with 12 mutations including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F.

Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?

PMID: 34206453 2021 Viruses

Introduction: Five mutations are located within NTD (L18F, T20N, P26S, D138Y, R190S), three in RBD (K417T, E484K, N501Y), two in the C-terminal domain of S1 and near the furin cleavage site (D614G, H655Y), and one in S2 (T1027I) (Figure 3).

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