literature

SARS_CoV_2 mutation literature information.

Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia.

PMID: 34933126 2022 Infection, genetics and evolution

Result: The mutations p.Lys1191Asp (K1191D), p.Glu484Lys (E484K), p.Leu18Phe (L18F), p.Pro26Ser (P26S), p.His655Tyr (H655Y), p.Asp614Gly (D614G), that along with other nucleotide substitutions constitute some of the VOC and VOI, were also identified, but not necessarily defining a complete lineage of interest.

Table: Table: H655Y

Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines.

PMID: 34906769 2022 Biomedicine & pharmacotherapy

Introduction: In the spike protein of the B.1.1.28 strain, there are eleven mutations, including L18F, T20N, P26S, D138Y, R190S, H655Y, T1027I, D614G, K417T, E484K, and N501Y.

Table: H655Y

Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.

PMID: 34896696 2022 Journal of infection and public health

Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,

A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.

PMID: 34896524 2022 Gene

Table: H655Y

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.

PMID: 34890524 2022 Emerging microbes & infections

Result: There are 32 mutations on the Spike of Omicron, including the following sites: A67V, H69del-V70del, T95I, G142D-V143del-Y144del-Y145del, N211del-L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H,

PMID: 34848355 2022 Infection, genetics and evolution

Table: H655Y

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses.

PMID: 34836485 2022 Emerging microbes & infections

Result: And when we went back to sequence the viruses from earlier passages, only H655Y, which has also been found in other circulating variants such as P.1, and V1128A were found.

Result: Indeed, when these mutations were introduced into pseudoviruses and tested for their sensitivity to 2-36, only K378 T alone or in combination with the other mutations was found to be resistant to 2-36, whereas viruses with T284I, H655Y, or V1128A alone remained sensitive (Figure 4D).

Result: Sequence analyses of the passage 12 virus revealed four single point spike mutations (T284I, K378 T, H655Y, V1128A), all

Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.

PMID: 34740719 2022 Virus research

Table: H655Y

Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants.

PMID: 34537361 2022 Clinical microbiology and infection

Abstract: Assessment of H655Y (n = 139) yielded a 100.0% concordance when applied in the proposed algorithm.

Abstract: METHODS: PCR SNP assays targeting SARS-CoV-2 S-gene mutations DeltaH69-V70, L452R, E484K, N501Y, H655Y and P681R using melting curve analysis were performed on 567 samples in which SARS-CoV-2 viral RNA was detected by a multiplex PCR.

Method: Using a 1-step protocol, cDNA was prepared from the RNA extracts and amplified on a LightCycler 480II (Roche Diagnostics, Rotkreuz, Switzerland) applying VirSNiP SARS-CoV-2 Spike N501Y, del H69/V70 (DeltaH69-V70), E484K, H655Y,

PMID: 34240429 2022 Allergy

Table: H655Y

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