Result: P.1 defining mutations related to each genomic region were the following: ORF1ab: S1188L, K1795Q, E5665D; spike: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I; Orf8: E92K; and nucleocapsid: P80.
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Discussion: Of the 10 new amino acid mutations in the spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) compared to its immediate ancestor (B.1.1.28), molecular selection analyses found evidence that 8 of these 10 mutations are under diversifying positive selection.
Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage.
Result: 4C demonstrated that the insertion in the NTD and H655Y mutation identified in high-passage-number WA1/2020 did not abrogate furin-mediated processing of S protein.
Result: A second dominant mutation, H655Y, was in the CTD2 domain.
Result: It was less abundant than the above insertion and H655Y mutation and present in a smaller fraction of viral genomes, and its frequency was not increasing.
Result: The H655Y mutation was already abundant in P5 virus and thus could not directly increase viral infectivity, at least while being alone.
The Emergence and Spread of Novel SARS-CoV-2 Variants.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of medical virology
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