Introduction: For example, the P.1 lineage detected first in Brazil is characterized by several amino acid (AA) substitutions mostly located either in RBD or in NTD: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I, which are shown to reduce neutralization by some antibodies.
Table: H655Y
A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.
PMID: 34806033
2021
Current research in structural biology
Result: The linker region consists of variant stretches contributed from three prominent mutations A570D, H655Y, and P681 H/R along with D614G.
Result: The linker region with P681R and H655Y along with D614G were the main amino acid co-occurring substitutions.
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.
Introduction: Likewise, the other lineage defining mutations for variants of concern were absent in the A.27 genomes, with the exception of L18F and H655Y, which are both present in the gamma lineage.
Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.
Abstract: Here, we developed five SARS-CoV-2 spike gene primer pairs (5-SSG primer assay; 69S, 144S, 417S, 484S, and 570S) and verified their ability to detect nine key spike mutations (DeltaH69/V70, T95I, G142D, DeltaY144, K417T/N, L452R, E484K/Q, N501Y, and H655Y) using a Sanger sequencing-based assay.
SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.
Method: P2 stock was sequenced and confirmed Omicron with the following substitutions: E:T9I,M:D3G,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,ORF1a:K856R,ORF1a:L2084I,ORF1a:A2710T,ORF1a:T3255I,ORF1a:P3395H, PMID: 34925381
2021
Frontiers in immunology
Introduction: The Gamma P.1 variant encodes an S protein with 12 mutations (L18F, T20N, P26S, D138Y, R190S, K417N/T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F), two of which are in the RBD (E484K, and N501Y).
Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization.
Introduction: The Omicron spike in this study contained mutations A67V, Delta69-70, T95I, G142D, Delta143-145, Delta211, L212I, +214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K,
Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic Review.
PMID: 35008446
2021
International journal of molecular sciences
Discussion: Among 33 patients having positive NPS PCR for an average of 18 days, Voloch et al., observed a distinguishing pattern of mutations over the course of the infection mainly driven by increasing A U and decreasing G A signatures, including spike mutations (V362L, T553I, H655Y, A688V, S691F, S884F, V1176F).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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