literature

SARS_CoV_2 mutation literature information.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: H625R

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: As a result, the H625R-mutant spike protein may exhibit differential biochemical properties, which should be further investigated, since they may have a severe impact on the functionality of the protein, making the virus more transmissible and/or infectious.

Result: Even though two similar amino acids are substituted, based on the in silico protein structure analysis, H625R leads to subtle alterations in the spike protein folding (Figure 5).

Result: In addition to the characterized D614G mutation, a previously unknown point mutation within S gene, H625R (23436A>G), was found at a frequency of 5.7% in September samples.

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