Assessment of basic reproduction number (R0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh.
PMID: 33930563
2021
Infection, genetics and evolution
Result: The fusion peptide region, S' including heptad repeats HR1 and HR2 regions contains 3 (G769V, T791I, A783S), 2(S939Y D936Y), 1(K1191N) mutated regions, respectively.
Result: The remaining other sites were located in different regions within the protein, including L5F, D614G, G769V, E516Q, T791I, L518I.
Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan.
Method: We designed a Custom TaqMan assay for detecting SARS-CoV-2 spike protein with the W152L and G769V mutations (Thermo Fisher Scientific).
Result: A consecutive analysis detected the W152L/E484K/G769V mutations in three patients who provided samples on January 14, 2021.
Result: Among the
Figure: An allelic discrimination plot of the results, showing the spike variants with W152L (upper), E484K (middle), and G769V (lower).
Figure: The R.1 lineage acquired its spike W152L and G769V mutations at the root.
Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.
PMID: 34121839
2021
Bioinformatics and biology insights
Table: G769V
A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic.
Discussion: Nonetheless, specifically for mutations such as G769V, mutational frequency data prompted the suggestion they do not impede the evolutionary stability of the virus.
Discussion: The only common S protein mutation identified in the B.1.2 lineage in this study was D614G, while detected uncommon S protein mutations included G769V, A942V and S1170X (Tables S2 and S3).
Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh.
Result: The fusion peptide region, S' including heptad repeats HR1 and HR2 regions contains 3 mutated regions (G769V, A783S, T791I), 2 (D936Y, S939Y), 1 (K1191N), respectively.
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences.
PMID: 34303698
2021
The American journal of pathology
Result: R.1 has the following core spike protein amino acid changes: W152L, E484K, D614G, and G769V (Outbreak.info, https://outbreak.info/situation-reports?pango=r.1, last accessed May 17, 2021).
Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.
Result: WGS analysis of the selected samples revealed that the 501N + 484K type is an R.1 lineage (W152L, E484K, D614G, G769V) variant, which is the sublineage of B.1.1.316.
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Infection, genetics and evolution
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