Introduction: Among 51 non-synonymous mutations in ORF3a, Q57H (17.4%) and G251V (9.7%) were predominant ones of which Q57H mutation was found to cause disease severity in hospitalised.
Introduction: The clade G, S and V comprise variants of S:D614G (23403A>G), ORF8:L84S (8782C>T) and ORF3a:G251V (26144G>T), respectively (Table 2).
Table: G251V
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Introduction: Based on GISAID classification, the clade L is considered as wild-type (WT) variant, which consists of initial isolates from China (including reference genome) or other countries mainly involved in the first stage of pandemic; the clade S is defined by L84S mutation in NS8; the clade V is defined by G251V mutation in NS3; the clade G is defined by D614G mutation in S-protein (dominant isolate since spring 2020).
Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.
Discussion: Clade V is hallmarked by 2 nonsynonymous variants, 11083G>T (L37F ORF1ab) and 26144G>T (G251V ORF3a), leading to alterations in the NSP6 and NS3 proteins, respectively.
Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology.
Introduction: Such changes include: L84S in NS8 for clade S; coexisting L37F and G251V mutations in NSP6 and NS3, respectively for clade V; D614G mutation in the spike protein (S) for clade G.
Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications.
Introduction: The recent temporal analyses of SARS-CoV-2 epidemics highlighted selective global sweep of the D614G variant S protein (Clade G) over G251V in ORF3a (Clade V) and L84S in ORF 8 (Clade S) variants.
Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2.
Result: However, the 10 amino acid substitutions recurred in SARS-CoV-2, i.e., I789V of papain-like protease, H36Y and V354F of spike-S1, G251V of ORF3a, D209H of membrane glycoprotein, V62L, L84S, and P85S of ORF8, and S194L, S202N, and P344S of nucleocapsid phosphoprotein (Figure 3E).
Result: In addition, epidemiological and evolutionary data for H36Y, N341D
SARS_CoV_2 mutation literature information.
PMID: 
2021
Infection, genetics and evolution
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