literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions.

PMID: 33556558 2021 Infection, genetics and evolution

Result: Among these sites, a subset of 11 early high-frequency sites (of which 8 were coding [ORF8 -L84S, ORF1a - V378I, ORF1a - L3606F, ORF1a - A3220V, ORF3a - G251V, ORF1a - L3606F, S - D614G, ORF1b - P314L]) enabled defining the phylogenetic clade structure of the viral sequences.

Table: G251V

Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus).

PMID: 33568759 2021 Scientific reports

Conclusion: The mutation G251V occurring in 206 sequences is also a prevalent mutation in the ORF3a protein.

Table: G251V

Figure: Protein ORF3a: two spikes at Q57H (2795) and G251V (206); protein ORF8: two spikes at S24L (320) and L84S (1000); protein N: R203K (876) and G204R (433); Other proteins E, M, ORF6, ORF7a, ORF7b and ORF10 are almost

Isolation and genetic characterization of SARS-CoV-2 from Indian patients in a single family without H/O travel abroad.

PMID: 33683658 2021 Virus genes

Result: The sequence (GenBank accession No MT066156) was similar to Wuhan, China, except for a unique G251V mutation forming a separate clade V.

A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.

PMID: 33705994 2021 Computers in biology and medicine

Discussion: Spike-D614G, Nsp3-G251V, Nsp3: F106F, Nsp12b: P314L, ORF3a: Q57H, ORF8-L84S, N: RG203KR, and 5'UTR:241 were the most frequent mutations in global SARS-CoV-2 isolates similar to earlier analyses.

Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines.

PMID: 33724631 2021 Reviews in medical virology

Table: G251V

Genomic characterization of a novel SARS-CoV-2.

PMID: 32300673 2020 Gene reports

Table: G251V

The origin of SARS-CoV-2 in Istanbul: Sequencing findings from the epicenter of the pandemic in Turkey.

PMID: 32478289 2020 Northern clinics of Istanbul

Discussion: Clades were named based on variants L84S in ORF8 (S clade), D614G in S gene (G clade), and G251V in ORF3a (V clade).

Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.

PMID: 32515358 2020 Journal of biosciences

Table: G251V

Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type.

PMID: 32474553 2020 The Indian journal of medical research

Table: G251V

Discussion: The C type defined by G26144T (ORF3a:G251>V) is the A1a type of this study.

SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East.

PMID: 32543353 2020 Emerging microbes & infections

Abstract: Genomes of 5 strains sequenced from clustered infections were classified into a new clade with ORF1ab-V378I mutation, in addition to 3 dominant clades ORF8-L84S, ORF3a-G251V and S-D614G.

Introduction: Three major clades, including clade G (with G variant at position 614 within the spike protein, as S-D614G), clade S (ORF8-L84S), and clade V (ORF3a-G251V), were designated by the GISAID (https://www.gisaid.org/hcov

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