Abstract: The results showed that four types of mutations caused dramatic changes in protein structures (RMSD >= 5.0 A), which were Q57H and G251V in open-reading frames 3a (ORF3a), S194L, and R203K/G204R in nucleocapsid (N).
Result: 11 After structural alignment, we found that four mutants exhibited a significant difference in protein structural morphology from their control ones (RMSD >= 5.0 A), which were Q57H Orf3a, G251V Orf3a, S194L N, a
A Founder Effect Led Early SARS-CoV-2 Transmission in Spain.
7Figure: The red star indicates the sequence associated with the Contamines-Monjoie cluster, and ""V"" indicates the presence of the G251V mutation in ORF3a protein."
Result: Several sequences from Spain were distributed throughout clade 19A, which includes 13 Spanish sequences harboring the G251V substitution in ORF3 (GISAID clade V), 7 genomes included in GISAID group O, and 3 other sequences in GISAID group L.
Result: The remaining 23 genome sequences branched within clade 19A (7.9%), including 13 sequences presenting the G251V substitution in ORF3 (4.5%) and 10 without this genetic marker (3.4%) (Table S1).
Result: This phylogenetic cluster included sequences with the G251V substitution in ORF3 protein along with other sequences without any of the major clade-defining residues.
Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection After Recovery from Mild Coronavirus Disease 2019.
1Abstract: The spike protein D614G substitution that defines the clade ""G"" emerged in reinfection, while mutations that characterize the clade ""V"" (ie, nsp6 L37F and ORF3a G251V) were present at initial infection."
5Result: Of these, nsp6 L37F and ORF3a G251V were the key substitutions that characterized clade ""V""."
Abstract: By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study.
Result: Orf3a-G251V was the most frequent amino acid substitution; 44/50 (88.0%) of the samples harbored this mutation, after which Orf1ab-H3233Y (30/50, 60.0%) and S-L8V (27/50, 54.0%) were most common.
Result: The second group originated with a single robust node with bootstrap value of 94% and a common mutation Orf3a-G251V.
Discussion: However, our sequencing result demonstrated that the genome of case 66 was 100% identical to
SARS-Cov-2 ORF3a: Mutability and function.
PMID: 33359807
2021
International journal of biological macromolecules
Result: Among these mutations, the variant G251V is consistently highly frequent and has been isolated all over the world.
Association of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India.
PMID: 33508515
2021
Infection, genetics and evolution
Result: There were 17 variants [C1707U, C6310A, U8022G, G11083U, A8026U, G11083U, G12685U, A15435G, C19524U, A21550C, A21551U, A24389U, G24390C, U24622C, C28311U, G29742U, A29827U, A29830U] that could not be included in the network analysis because of the presence of unresolved bases at multiple viral genome sequences and the G26144U (ORF3a:G251V) variant that segregates clade V was excluded because of allele frequency cutoff of 1%.
A global analysis of replacement of genetic variants of SARS-CoV-2 in association with containment capacity and changes in disease severity.
PMID: 33524589
2021
Clinical microbiology and infection
Method: With reference to GISAID, variants were assigned to four lineages: L (reference sequence, nucleotide T28144, ORF8 amino acid L84), S (nt T28144C, ORF8 aa L84S), V (nt G26144T, ORF3a aa G251V) and G* (nt A23403G, S gene aa D614G).
Variations in Orf3a protein of SARS-CoV-2 alter its structure and function.
PMID: 33527091
2021
Biochemistry and biophysics reports
SARS_CoV_2 mutation literature information.
PMID: 
2021
Current research in microbial sciences
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