Abstract: The viral sequence from infected zoo lions belonged to clade V, and a single mutation of G251V is found for ORF3a gene compared to all other clades.
Introduction: According to the data from the Global Initiative on Sharing All Influenza Data (GISAID; https://www.gisaid.org), four major clades of SARS-CoV-2 have so far been identified and named clade L (prototype virus Wuhan-Hu-1; GenBank accession number NC_045512), clade G (D614G variant of the spike protein), clade V (G251V variant of ORF3a), and clade S (L84S variant of ORF8).
Result: 6A), it was of interest to see if a single amino acid change from G to V at position 251<
SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence.
Result: conducted in China showed no significant differences between two variants (clade I (ORF3a: p.251G > V, or S: p.614D > G (subclade G)); clade II (ORF8: p.84L > S (28,144U > C) and ORF1ab: p.2839S (8782C > U)) regarding disease severity and blood parameters indicative of severity.
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Result: The combination of G251V and L37F, which was initially considered a defining mutation pattern for the B.2 to B.6 lineage (clade V in GISAID classification), has shown under more detailed analysis that isolates carrying the G251V mutation are distributed in other lineages too.
Result: The subsequent amino acid substitutions L37F in ORF3a and G251V in nsp6 were found to be present in 13.3% and 1.4% of genomes, respectively.
Table: G251V
Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.
PMID: 34540148
2021
Iranian journal of microbiology
Table: G251V
Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution.
Abstract: As a consequence, for global dataset without Indian sequences, G251V in ORF3a in clade 19A, F308Y and G196V in NSP4 and ORF3a in 19B are the unique amino acid changes which are responsible for defining each clade as they are all deleterious and unstable.
Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.
PMID: 34606987
2021
Infection, genetics and evolution
Result: In addition, very high rate recurrent mutations exist at the following locations: spike protein; D614G, nucleocapsid phosphoprotein; S194L, R203K and G204R, ORF3a; Q57H and G251V, and ORF8; L84S.
Table: G251V
Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.
PMID: 34735950
2021
Computers in biology and medicine
Discussion: G251V results in the loss of a phosphatidylinositol-specific phospholipase X-box domain and a creation of a serine protease cleavage site.
Discussion: Another work states that G251V and G196V might influence virulence, infectivity, ion channel activity, and viral release.
Discussion: However, in the present research G26144T (G251V) was found to create a cluster on its own; the mutation was featured by increased age (57) and an increased proportion of women compared to the general cohort.
Discussion: Only three mutations have not been noted in the uploads for some time: G26144T (G251V) and G25979T (G196V) in ORF
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Discussion: GISAID differentiates COVID-19 into three major clades: Clade S, Clade V and Clade G (originally prevalent in North America, Asia/Europe, and Europe, respectively), based on NS mutations at NS8_L84S, NS3_G251V and S_D614G, respectively.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Scientific reports
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