Result: For the four other hotspot mutations were distributed in ORF3a (Q57H and G251V) and nucleocapsid phosphoprotein (R203K and G204R).
Result: SARS-CoV-2 genomes also harbored three co-occurrent mutations R203K, R203R and G204R in the N protein and were present in all continents except Africa and Asia (besides Taiwan).
Result: The first subcluster SCB3 harbored strain sharing two mutation R203K (N) and G204R (N) harboring largely strains from Europe and some strains from North Africa (Franc
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
Result: In addition to the three type VI signature SNVs, five additional subtype SNVs with variation frequencies of >0.1 included C1059T (nsp2, T265I), G25563T (ORF3a, Q57H), G28881A (N, R203K), G28882A (N, R203K), and G28883C (N, G204R).
Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.
Discussion: Interestingly, these three variants always occurred together, and sometimes they were accompanied by a synonymous mutation C241T (in 39 genomes) or multiple nucleotide substitutions GGG28881..28883AAC (N: R203K, G204R; in 33 genomes), suggesting linkage of mutations among these strains.
Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A (R203K, N gene), 28882 G > A (R203R, N gene), 28883 G > C (G204R, N gene), and
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.
Result: The impact of this variation, corresponding to a double mutation at the protein level (Arg203Lys and Gly204Arg), results in an additional positively charged site, and possibly, it increases local rigidity with the subtraction of Gly204.
Result: The wavelet analysis simultaneously displays the location, frequency, and mutational density at different scales and identified a cluster of moderately frequent mutations involving 14 amino acids in a serine/arginine-rich motif of N (Ser180Ile, Ser183Tyr, Ser188Leu, Ser190Asn, Ser193Ile, Ser194Leu, Arg195Lys, Ser197Leu, Ser202Asn
SARS_CoV_2 mutation literature information.
PMID: 
2020
PloS one
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