Introduction: In addition, an Nsp12 mutation (P323L) and N protein double mutations (R203K and G204R) were also found.
Discussion: Siqi suggested that R203K and G204R mutations could change viral protein structure, binding affinity, and hot spots of the interface, thereby impact on SARS-CoV-2 transmission, diagnosis, and treatment of Discussion: These changes translated to four amino acid changes in three proteins: spike (D614G), Nsp12 (P323L), and N protein (R203K and G204R).
Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies.
Introduction: Omicron also had mutations in the other structural proteins, including Envelope (E) (T9I), Membrane (M) (D3G, Q19E, and A63T), and Nucleocapsid (N) (P13L, Delta31-33, R203K, G204R), further enhancing their infectivity.
Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.
Figure: (B) 28881-3 GGG/AAC (R203K and G204R)) mutations in the nucleocapside protein coding gene in Clustal Omega.
Figure: (Bottom) This panel shows the domain organization of the variant SARS-CoV-2 N-protein with mutations at position 203 and 204 (R203K, G204R).
Discussion: S2, S3 and S5, shared rare set of three contiguous mutations in their genome which resulted in the consecutive alterations of R203K and G204R.
Discussion: We also analysed the predicted structural alterations in the viral nucleocapsid protein, which might be caused by consecutive alterations of R203K and G204R.
SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East.
Result: We further found 4 Taiwanese strains (CGMH-CGU-12, -13, -18, and -20, top four in Figure 3E) shared the same N gene mutations R203K and G204R resulting from 3 nucleotide mutations G608A, G609A, and G610C.
Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey.
Discussion: These mutations were due to nucleotide substitutions in 3 nucleotides in order where 2 of them (G28881A and G28882A) results in arginine to lysine (R203K) substitution and the third one (G28883C) results in glycine to arginine (G204R) in the nucleocapsid phosphoprotein, where both substituted amino acids differ from their original amino acids in means of their isoelectric points (Pachetti et al., 2020) (Table 1).
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Result: In the cluster 2, K/R variants of N protein R203K/G204R mutations were significantly enriched at 43.1%, compared with the other clusters (5.2%, P = 0.00011 for the cluster 1 and 11.8%, P = 5.6 x 10-7 for the cluster 3; Supplementary.
Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide.
Introduction: For example, most strains of the D614G clade also harbor a mutation (P4715L) in orf1ab and a subclade processes three nucleotide changes in the nucleoprotein (N) gene (GGG to AAC; G204R), which plays diverse roles in virion assembly as well as genome transcription and translation.
Molecular Epidemiology Analysis of SARS-CoV-2 Strains Circulating in Romania during the First Months of the Pandemic.
Result: Additionally, SNV signatures of previously characterized Brazilian genomes were found in most samples, such as G28881A and G28882A (98.6%; resulting in R203K change in N), G28883C (98.6%; resulting in G204R change in N), T27299C (91.6%; resulting in I33T change in ORF6), and T29148C (90.1%; resulting in I292T change in N).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in medicine
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