Result: Although substitution mutations, R203K, G204R at nucleocapsid and P323L at NSP12 were detected in ~90% of the isolates in Japan, the frequency reduced during January to February 2021.
Result: Among 22 point mutations at N and other eight non-structural proteins, eight namely, N_S194L, N_R203K, N_G204R, NS3_Q57H, NSP2_T85I, NSP5_G15S, NSP6_
Table: G204R
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.
Result: (iii) Two neighboring variants in nucleocapsid, R203K and G204R (Figure 5C), showed roughly similar frequencies over time in the same geographic areas.
Result: Fifteen variants with the prevalence >5% were identified, including (i) four variants in nucleocapsid: S194L (6.29%), R203K (28.45%), G204R (28.13%), and A220V (25.96%); (ii) four variants in spike: L18F (12.08%), A222V (26.14%), S477N (6.62%), and D614G (93.88%); (iii) two variants in NSP2: T85I (15.38%
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Result: In addition, several aa substitutions can be seen in the NSP3 (S370L, K977Q), NSP12 (P323L), and NSP13 (E341D), NS3 (S253P), NS8 (E92K), N-protein (P80R, R203K, G204R).
Result: Moreover, the UK-VOC contains several aa substitutions in other genomic regions, including NSP3: T183I, A890D, I1412T, NSP12:
SARS-CoV-2 mutations: the biological trackway towards viral fitness.
Introduction: Cluster I includes 3037C>T; NSP3:F106F (non-structural protein3:F106F) and 14408C>T; RdRp:P323L, cluster II includes 3037C>T, 14408C>T and 23403A>G; S:D614G, cluster III includes 14408C>T, cluster IV includes 3037C>T, 14408C>T, 23403A>G, 28881G>A; N:R203K, 28882G>A
Assessment of basic reproduction number (R0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh.
PMID: 33930563
2021
Infection, genetics and evolution
Abstract: Alternatively, I120F in NSP2 protein, R203K and G204R in nucleocapsid protein, and P323L in RdRp were more recurrent.
Result: Besides all other essential protein, another most abundant changes were observed in the N protein (R203K, G204R), which is mainly targeted in the diagnostics purposes.
D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect.
Result: In addition, the GH clade presents the NS3-Q57H mutation, the GR clade presents the N-G204R mutations, and GV clade presents the S-A222V mutation.
Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.
PMID: 33966351
2021
Transboundary and emerging diseases
Result: Interestingly, three sequential SNP sites (28881-3.GGG>ACA) were fixed in 22% (207/951) of the European SARS-CoV-2 isolates, resulting in a synonymous mutation and two missense mutations (Arg 203 Lys and Gly 204 Arg) (Table 1).
Table: Gly204Arg
Genomic epidemiology of SARS-CoV-2 in Esteio, Rio Grande do Sul, Brazil.
Abstract: RESULTS: We provided a comprehensive view of mutations from a representative sampling from May to October 2020, highlighting two frequent mutations in spike glycoprotein (D614G and Conclusion: Our results provide a comprehensive view of SARS-CoV-2 mutations from a time- and age-representative sample from May to October 2020, highlighting two frequent mutations in spike glycoprotein (D614G and V1176F), an emergent mutation in spike RBD (E484K) characteristic of B.1.351 and P.1 lineages, and the adjacent replacement of 2 amino acids in Nucleocapsid phosphoprotein (R203K and G204R).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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