Method: P2 stock was sequenced and confirmed Omicron with the following substitutions: E:T9I,M:D3G,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,ORF1a:K856R,ORF1a:L2084I,ORF1a:A2710T,ORF1a:T3255I,ORF1a:P3395H, PMID: 34866979
2021
Saudi journal of biological sciences
Result: Other changes which were frequently identified include G25563T (G57H) and C26735T (silent) each of which occurred in 33 variants, followed by C18877T (silent), G28881A (S202N) and G28883C (G204R) which appeared in 32, 23 and 22 variants respectively.
Discussion: All structural genes in our study showed missense mutations except E gene which showed only one silent mutation; N gene showed highest mutations among the structural genes, the most frequent mutations at positions G28881A (S202N), and G28883C (
Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2.
Discussion: In summary, we identified the adaptation of the N protein mutations R203K/G204R through thorough in silico evolutionary analyses.
Discussion: Using the authentic virus, we proved that R203K/G204R increase viral replication, which enhances the infectivity, fitness, and virulence of SARS-CoV-2.
Discussion: We found that the increase in infectivity was due to the promotion of virus replication efficiency, which may have been caused by the change in the local charge of the N protein resulting from the R203K/G204R mutations.
Discussion: We have performed analyses and experiments on R203K/G204R mutant virus.
Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.
PMID: 34812411
2021
Informatics in medicine unlocked
Discussion: Along with the previously found GGG > AAC mutation, our mutational type analysis identify some another multi-nucleotide mutations CC > TT, TG > CA, and AT > TA which are in the top 20 mutational type and should be monitored for the future as the GGG > AAC (R203K and G204R) reported to be associated with the insertion of a lysine in SR domain of N protein which might affect the phosphorylation.
Re-emergence of Gamma-like-II and emergence of Gamma-S:E661D SARS-CoV-2 lineages in the south of Brazil after the 2021 outbreak.
Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.
PMID: 34606987
2021
Infection, genetics and evolution
Abstract: High recurrent mutations, namely: T265I in non-structural protein 2 (nsp2), L3606F in nsp6, P4715L in RNA-dependent RNA polymerase (RdRp), D614G in spike glycoprotein, R203K and G204R in nucleocapsid phosphoprotein and Q57H in ORF3a with well-conserved envelope and membrane proteins, 3CLpro and spike S2 domains across regions were observed.
Result: In addition, very high rate recurrent mutations exist at t
The evaluation of potential global impact of the N501Y mutation in SARS-COV-2 positive patients.
Method: Next, in the set of genomes found, we verified all mutations, excluding those that define the B.1.1.28 lineage (C241T, F924F, P4715L, D614G, V1176F, R203K, R203R and G204R).
SARS_CoV_2 mutation literature information.
PMID: 
2021
PloS one
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