Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Result: The N_G204R mutation was reported at 22.31%, 75.69%, 46.59%, 52.36% and 76.01% in SARS-CoV-2 genome sequences isolated from Africa, Asia, Australia, Europe and South America, respectively.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Result: After the importation of B.1.1 lineages characterized by N:R203K and N:G204R mutations, community transmission massively occurred and gave rise to B.1.1.28 (S:V1176F) and B.1.1.33 lineages (ORF6:I33T and N:I292T), widely distributed in Brazilian regions along the first year of the pandemic.
SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.
PMID: 34425504
2021
Diagnostic microbiology and infectious disease
Conclusion: In addition, both sequences presented the R203K and G204R aminoacid change in the nucleocapsid (N) protein.
Table: G204R
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
Result: Consistent with this study, we identified R203K, G204R, S194L, and M234I in the nucleocapsid protein as shared mutations between Columbia and Rock Hill WWTP influents in January 2021 (Supplementary Table S3).
Result: In particular, R203K and G204R both had a mutation rate of 0.22, indicating that they were present in 22% of all sequences as of December 2020.
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
PMID: 34445204
2021
International journal of molecular sciences
Result: Consequently, the absence of R203 residue is expected to have an immediate impact on the N protein folding and functionality, while any of the variations in position 204 of the protein (G204R, G204L, or G204H) lead only to subtle modifications (Figure 5).
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Abstract: We identified multiple missense mutations in B-cell and T-cell predicted epitope regions and/or PCR target regions (including R203K and G204R that occurred in 86% of the isolates) that may impact immunogenicity and/or RT-PCR based diagnosis.
Result: About 88% of the sequences clustered in GR clade the distinctive feature of which is G204R mutation in the nucleocapsid protein (Figure 4 and Table 3).
Result: Beside these, two of the high frequency (86%) SNVs (R203K and G204R) occurred in COVID-19 diagnostic RT-PCR target and B-Cell predicted epitope regions, of which the later was predicted to cause altered function of the nucleocapsid
Table: G204R
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
Diagnostic pre-screening method based on N-gene dropout or delay to increase feasibility of SARS-CoV-2 VOC B.1.1.7 detection.
PMID: 34464903
2021
Diagnostic microbiology and infectious disease
Result: Mutations detected in the N protein of all samples analyzed were M1X, D3L, R203K, G204R and S235F.
Discussion: Other mutations detected in all samples analyzed, such as M1X, R203K and G204R, could affect the amplification efficiency of the N-gene target.
Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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