literature

SARS_CoV_2 mutation literature information.

Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.

PMID: 34540148 2021 Iranian journal of microbiology

Table: G204R

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.

PMID: 34541432 2021 Pathogens & immunity

Result: Interestingly, the increased levels of ORF9b may be due to the D3L mutation in the nucleocapsid that we have proposed to have arisen similarly to the R203G/G204R mutations and is associated with increased levels of B.1.1.7 sgRNA encoding ORF9b in clinical samples.

Result: Notably, SARS-CoV-2 R203K/G204R polymorphisms modify the predicted binding of putative HLA-restricted T-cell epitopes containing these residues (Supplemental Table 2).

Result: Of the 455,774 circulating variants there were 29 amino acid polymorphisms present in >5% of the deposited sequences (of a total of 9413 sites; Supplemental Table 1) including the spike D614G variant (B.1 lineage) that emerged early in the pandemic and th

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Abstract: High recurrent mutations, namely: T265I in non-structural protein 2 (nsp2), L3606F in nsp6, P4715L in RNA-dependent RNA polymerase (RdRp), D614G in spike glycoprotein, R203K and G204R in nucleocapsid phosphoprotein and Q57H in ORF3a with well-conserved envelope and membrane proteins, 3CLpro and spike S2 domains across regions were observed.

Result: In addition, very high rate recurrent mutations exist at t

The Emergence of the New P.4 Lineage of SARS-CoV-2 With Spike L452R Mutation in Brazil.

PMID: 34660520 2021 Frontiers in public health

Method: Next, in the set of genomes found, we verified all mutations, excluding those that define the B.1.1.28 lineage (C241T, F924F, P4715L, D614G, V1176F, R203K, R203R and G204R).

The evaluation of potential global impact of the N501Y mutation in SARS-COV-2 positive patients.

PMID: 34676574 2021 Journal of medical virology

Table: G204R

Dominant clade-featured SARS-CoV-2 co-occurring mutations reveal plausible epistasis: An in silico based hypothetical model.

PMID: 34676891 2021 Journal of medical virology

Introduction: The GR clade or lineage B.1.1.* is classified with additional trinucleotide mutations at 28 881-28 883 (GGG>AAC), creating two consecutive amino acid (aa) changes, R203K and G204R, in N protein.

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: Twelve signature amino acid mutations (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F) were observed in the S protein as well as other consensus changes, including ORF1a (S1188L and K1795Q), ORF1b (P214L and E1164D), ORF3a (S253P),

PMID: 34730486 2021 Microbial genomics

Result: The most frequent substitutions among sequences were L71F (22.6 %) in the NSP7; P303L (99 %) in the RNA-dependent RNA polymerase (RdRp); D614G (98.5 %) and V1176F (41%) in the spike; I33T (37.4 %) in the ORF6; R203K (93.5 %), G204R (93.8 %), and I292T (39 %) in the N protein (Table S1).

Discussion: Additionally, the N protein also showed positive selection pressure in the sites S202C/I and

Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and Transmission.

PMID: 34733263 2021 Frontiers in microbiology

Result: D614G increased from 74.6% to 99.9%; T265I, Q57H, R203K, and G204R started to increase in March and gradually decreased in July (Figure 3D).

Discussion: Some of the mutation hotspots identified herein, namely, R203K, G204R, L3930F, and V1176F, were also high in severe cases, but significant statistical differences were not found.

Discussion: The R203K and G204R variants co-occurred in the N protein and caused dramatic changes in protein structure [root mean square deviation (RMSD) >=5.0 A], thus decreasing the flexibility of the domain.

Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.

PMID: 34735950 2021 Computers in biology and medicine

Discussion: Also, R203K and G204R in the N gene were found to occur together with high frequency, which is confirmed in our research.

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