literature

SARS_CoV_2 mutation literature information.

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

PMID: 34103090 2021 European journal of medical research

Table: G204R

Structural phylogenetic analysis reveals lineage-specific RNA repetitive structural motifs in all coronaviruses and associated variations in SARS-CoV-2.

PMID: 34141447 2021 Virus evolution

Abstract

Result: Curiously, deletion of the RGTSPA sequence in N protein is exclusively found in Cluster B (Table 2), and the R203K-G204R variations are highly constrained in Cluster B (Table 2) and E (Supplementary Table S3).

Result: Several non-synonymous variations are found differential between cluster A and B, for example, C14408U, A23403G, and G28881A-G28882A-G28883C resulting in Nsp12 P323L, S protein D614G, and N protein R203K-G204R, were found differ, respectively (Table 2).

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.

PMID: 34147651 2021 Infection, genetics and evolution

Result: N protein co-mutations

Result: For instance, additional mutations in Spike:D614G (Clade 3a) have led to: Clade 3b (Nsp12:P323L), Clade 3c (Nsp12:P323L and ORF3a:Q57H), Clade 3d (Nsp12:P323L, ORF3a:Q57H & Nsp2:T85I) and Clade 3e (Nsp12:P323L & N protein:R203K & G204R).

Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis.

PMID: 34154921 2021 Journal of infection and chemotherapy

Table: G204R

Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.

PMID: 34157472 2021 Computers in biology and medicine

Result: We have also noticed few other shared variations like R203K and G204R in nucleocapsid protein among the viral strains from Saudi Arabia and Russia, and the S166A variation in the viral strains from Saudi and India.

Table: G204R

High-precision and cost-efficient sequencing for real-time COVID-19 surveillance.

PMID: 34211026 2021 Scientific reports

Result: Ten of the 25 sequences shared additional mutations of R203K and G204R in the N (nucleocapsid) protein (skyblue circle in.

Table: G204R

Discussion: In addition to the G clade's other common mutation, NSP12-P323L, frequent mutations we observed include N-S194L, N-R203K, N-G204R, NSP2-T85I, and ORF3a-Q57H.

Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh.

PMID: 34251592 2021 Virus genes

Result: Moreover, several mutations were found that persisted, (I120F, T412I, L37F, P323L, G204R, R203K, and D614G) for more than 6 weeks (Table 1 and.

Discussion: On the other hand, the temporal analysis of mutation accumulation also showed mutations (P323L, I120F, D614G, R203K, G204R) that persist over a longer period of time.

Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines.

PMID: 34264104 2021 Microbiology resource announcements

Table: G204R

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Result: Other major mutations noted are Q57H (26.5%), R203K/G204R (33%), G15S (12%), I120F (11.5%), and T85I (14%).

Result: These are Q57H (nucleotide 25,563, G to T) in ORF3a, the R203K + G204R combination (nucleotide 28,881, GGG to AAC) in nucleocapsid, and T85I (nucleotide 1,059, C to T) in ORF1a.

Discussion: For example, many of the favorably selected variants, such as L18F, L5F (spike); R203K

Ongoing global and regional adaptive evolution of SARS-CoV-2.

PMID: 34292871 2021 Proc Natl Acad Sci U S A

Result: 3D and SI Appendix, Table S3; see Brief Methods), in which the central hubs are D614G in the spike (<

Figure: Black nodes correspond to key amino acid substitutions S L18F, S A222V, S S477N, S N501Y, S D614G, S P681H, S T716I, N R203K, and N G204R.

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