Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.
PMID: 34029587
2021
The Journal of biological chemistry
Discussion: Interestingly, the only variant in N protein is R203K;G204R in the B.1.17 strain and T205I in B.1.351 strain, suggesting the RGT sequence is an important regulatory site.
SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains.
Discussion: The European strain carries additional mutations, notably the hotspot mutations R203K and G204R, that cluster in a serine-rich linker region at the RdRp.
E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.
PMID: 34044192
2021
Infection, genetics and evolution
Result: S:D614G, N:R203K, Discussion: The occurrence of simultaneous mutations as N:R203K and N:G204R is already known in the SARS-CoV-2 literature.
Discussion: The presence of spike S:D614G, N:R203K, N:G204R, and Nsp12:P323L in all sequenced E484 mutated samples, reaching three different lineages, might suggest that these lineages show increased viral replication.
Identification of E484K and other novel SARS-COV-2 variants from the Kingdom of Bahrain.
Result: Four mutations were located within nonstructural proteins (Nsp3: T1246I, Nsp3: T1250I, Nsp5: G3278S, Nsp12: P4715L), three in the nucleocapsid (S2F, R203K, G204R), and two affecting the spike protein (D6
Discussion: Three variants were located within the N-protein coding gene, two of these polymorphisms refer to amino acid changes (R203K and G204R), which have been associated earlier to increased fitness and adaptation.
Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.
Discussion: Many other missense and synonymous mutations found in respective proteins of Bangladeshi virus populations such as ORF1ab/nsp12_P323L, NS3_Q57H, NS8_R52I, N_S194L, N_R203K, and N_G204R, which are also common worldwide.
Discussion: The GR clade, in which the N_G204R mutation in the nucleocapsid protein is combined with the widespread S_D614G mutation, accounted for around 83% of the Bangladeshi sequences.
An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.
Result: Firstly, the GR-GH variants defined by the presence of the D614G, G204R, and Q57H mutations in the S, N, and ORF3a proteins, respectively, were observed in 14 sequences from different parts of India, starting from May 2020 (Figure 2).
Result: Secondly, the GV-GR variant defined by the presence of A222V in the S and G204R mutations in the N protein, along with the common D614G mutation of the G clade, were observed starting from August 2020 in Maharashtra (n = 1) and Telangana (n = 2).
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: Clade GR (D614G + G204R in the nucleocapsid (N) protein; reference sequence: EPI_ISL_850687) is currently dominating Africa (41.1%), Asia (52.7%), Oceania (74.8%), and South America (66.8%), while GH (D614G + Q57H in the NS3 protein; reference sequence: EPI_ISL_861025) reigns in North America (59.0%).
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.
Result: Furthermore, various amino acid mutations were also found in the other proteins of virus samples, including on NSP2 (A205V, V247A, T256I, Q321K), NSP3 (P679S, T1022I, A1179V, T1198K, F1354C, P1665L), NSP4 (A231V), NSP5 (K12R, M49I, P184S), NSP6 (L37F), PMID: 34097716
2021
PLoS pathogens
Result: Among the missense mutations, four were in the spike protein (W152L, E484K, D614G, and G769V), four were in ORF1ab (T4692I, N6301S, L6337M, and I6525T), one was in the membrane protein (F28L), and four were in the nucleocapsid protein (S187L, R203K, G204R, and Q418H).
SARS_CoV_2 mutation literature information.
PMID: 
2021
The Journal of biological chemistry
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