Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.
PMID: 34812411
2021
Informatics in medicine unlocked
Discussion: Along with the previously found GGG > AAC mutation, our mutational type analysis identify some another multi-nucleotide mutations CC > TT, TG > CA, and AT > TA which are in the top 20 mutational type and should be monitored for the future as the GGG > AAC (R203K and G204R) reported to be associated with the insertion of a lysine in SR domain of N protein which might affect the phosphorylation.
Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.
Discussion: The recently evolved Indian lineages B.1.617.1 (Kappa), B.1.617.2 (Delta), and AY.1 (Delta-plus) also carry a point mutation at 28,881, which is a novel N mutation, R203M, instea
Discussion: Using the authentic virus, we proved that R203K/G204R increase viral replication, which enhances the infectivity, fitness, and virulence of SARS-CoV-2.
Discussion: We found that the increase in infectivity was due to the promotion of virus replication efficiency, which may have been caused by the change in the local charge of the N protein resulting from the R203K/G204R mutations.
Discussion: We have performed analyses and experiments on R203K/G204R mutant virus.
Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study.
PMID: 34866979
2021
Saudi journal of biological sciences
Result: Other changes which were frequently identified include G25563T (G57H) and C26735T (silent) each of which occurred in 33 variants, followed by C18877T (silent), G28881A (S202N) and G28883C (G204R) which appeared in 32, 23 and 22 variants respectively.
Discussion: All structural genes in our study showed missense mutations except E gene which showed only one silent mutation; N gene showed highest mutations among the structural genes, the most frequent mutations at positions G28881A (S202N), and G28883C (
SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.
Method: P2 stock was sequenced and confirmed Omicron with the following substitutions: E:T9I,M:D3G,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,ORF1a:K856R,ORF1a:L2084I,ORF1a:A2710T,ORF1a:T3255I,ORF1a:P3395H, PMID: 34910734
2021
PloS one
Result: Other commonly found mutations were Y453F (50.3%), S194L (49.4%), R203K (49.1%), and G204R (47.6%) in N protein of mink (Fig 13).
Introduction: In addition, an Nsp12 mutation (P323L) and N protein double mutations (R203K and G204R) were also found.
Discussion: Siqi suggested that R203K and G204R mutations could change viral protein structure, binding affinity, and hot spots of the interface, thereby impact on SARS-CoV-2 transmission, diagnosis, and treatment of COVID-19.
Discussion: These changes translated to four amino acid changes in three proteins: spike (D614G), Nsp12 (P323L), and N protein (R203K and
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in cellular and infection microbiology
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