literature

SARS_CoV_2 mutation literature information.

Genomic Diversity of SARS-CoV-2 in Algeria and North African Countries: What We Know So Far and What We Expect?

PMID: 35208920 2022 Microorganisms

Abstract: Phylogenetic analysis of SARS-CoV-2 genomes revealed the existence of eleven GISAID clades with GR (variant of the spike protein S-D614G and nucleocapsid protein N-G204R), GH (variant of the ORF3a coding protein ORF3a-Q57H<

Result: The time course of the phylogenetic analysis and clade distribution showed that clades G (Variant S-D614G), GH (Variant ORF3a-Q57H) and GR (Variant N-G204R) were the most prevalent in the first and second waves of viral introductions.

A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations.

PMID: 35222380 2022 Frontiers in immunology

Method: Simultaneously, some mutations such as R203K and G204R are too noted in the Omicron variant.

Clinico-Genomic Analysis Reiterates Mild Symptoms Post-vaccination Breakthrough: Should We Focus on Low-Frequency Mutations?

PMID: 35308382 2022 Frontiers in microbiology

Discussion: Moreover, the mutation R203K/G204R was found to display a different protein structure morphology from the control and an enhanced intraviral interaction of R203K/G204R in the N and E proteins in molecular docking and protein structure prediction analysis.

RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant.

PMID: 35293849 2022 Emerging microbes & infections

Method: Similarly, R203K/

Figure: (E) The specific differences in the R203M, R203K/G204R and T205I mutations in the N gene sequence.

Figure: Numbers 1-4: the amplified curve of the R203M, R203K/G204R, T205I mutant-containing template and wild template using the conserved primer set.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: The common mutations observed in N-protein are R203K and G204R.

Table: G204R

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Conclusion: In addition, both sequences presented the R203K and G204R aminoacid change in the nucleocapsid (N) protein.

Table: G204R

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Result: Consistent with this study, we identified R203K, G204R, S194L, and M234I in the nucleocapsid protein as shared mutations between Columbia and Rock Hill WWTP influents in January 2021 (Supplementary Table S3).

Result: In particular, R203K and G204R both had a mutation rate of 0.22, indicating that they were present in 22% of all sequences as of December 2020.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: Consequently, the absence of R203 residue is expected to have an immediate impact on the N protein folding and functionality, while any of the variations in position 204 of the protein (G204R, G204L, or G204H) lead only to subtle modifications (Figure 5).

Result: Five well-characterized missense mutations, D614G (23403A>G)-S gene, Q57H (25563G>T)-ORF3a gene, P323L (14408C>T):ORF1ab/RdRP gene, R203K (

Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.

PMID: 34363852 2021 Virus research

Result: After the importation of B.1.1 lineages characterized by N:R203K and N:G204R mutations, community transmission massively occurred and gave rise to B.1.1.28 (S:V1176F) and B.1.1.33 lineages (ORF6:I33T and N:I292T), widely distributed in Brazilian regions along the first year of the pandemic.

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Result: The N_G204R mutation was reported at 22.31%, 75.69%, 46.59%, 52.36% and 76.01% in SARS-CoV-2 genome sequences isolated from Africa, Asia, Australia, Europe and South America, respectively.

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