Result: Among the missense mutations, four were in the spike protein (W152L, E484K, D614G, and G769V), four were in ORF1ab (T4692I, N6301S, L6337M, and I6525T), one was in the membrane protein (F28L), and four were in the nucleocapsid protein (S187L, R203K, G204R, and Q418H).
Table: G204R
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
PMID: 34445204
2021
International journal of molecular sciences
Result: Consequently, the absence of R203 residue is expected to have an immediate impact on the N protein folding and functionality, while any of the variations in position 204 of the protein (G204R, G204L, or G204H) lead only to subtle modifications (Figure 5).
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
Result: Consistent with this study, we identified R203K, G204R, S194L, and M234I in the nucleocapsid protein as shared mutations between Columbia and Rock Hill WWTP influents in January 2021 (Supplementary Table S3).
Result: In particular, R203K and G204R both had a mutation rate of 0.22, indicating that they were present in 22% of all sequences as of December 2020.
SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.
PMID: 34425504
2021
Diagnostic microbiology and infectious disease
Conclusion: In addition, both sequences presented the R203K and G204R aminoacid change in the nucleocapsid (N) protein.
Table: G204R
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Result: After the importation of B.1.1 lineages characterized by N:R203K and N:G204R mutations, community transmission massively occurred and gave rise to B.1.1.28 (S:V1176F) and B.1.1.33 lineages (ORF6:I33T and N:I292T), widely distributed in Brazilian regions along the first year of the pandemic.
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Result: The N_G204R mutation was reported at 22.31%, 75.69%, 46.59%, 52.36% and 76.01% in SARS-CoV-2 genome sequences isolated from Africa, Asia, Australia, Europe and South America, respectively.
Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis.
PMID: 34154921
2021
Journal of infection and chemotherapy
Table: G204R
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.
PMID: 34157472
2021
Computers in biology and medicine
Result: We have also noticed few other shared variations like R203K and G204R in nucleocapsid protein among the viral strains from Saudi Arabia and Russia, and the S166A variation in the viral strains from Saudi and India.
Table: G204R
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Table: G204R
High-precision and cost-efficient sequencing for real-time COVID-19 surveillance.
Result: Ten of the 25 sequences shared additional mutations of R203K and G204R in the N (nucleocapsid) protein (skyblue circle in.
Table: G204R
Discussion: In addition to the G clade's other common mutation, NSP12-P323L, frequent mutations we observed include N-S194L, N-R203K, N-G204R, NSP2-T85I, and ORF3a-Q57H.
SARS_CoV_2 mutation literature information.
PMID: 
2021
PLoS pathogens
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