Discussion: Interestingly, these three variants always occurred together, and sometimes they were accompanied by a synonymous mutation C241T (in 39 genomes) or multiple nucleotide substitutions GGG28881..28883AAC (N: R203K, G204R; in 33 genomes), suggesting linkage of mutations among these strains.
Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A (R203K, N gene), 28882 G > A (R203R, N gene), 28883 G > C (G204R, N gene), and
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.
Result: The impact of this variation, corresponding to a double mutation at the protein level (Arg203Lys and Gly204Arg), results in an additional positively charged site, and possibly, it increases local rigidity with the subtraction of Gly204.
Result: The wavelet analysis simultaneously displays the location, frequency, and mutational density at different scales and identified a cluster of moderately frequent mutations involving 14 amino acids in a serine/arginine-rich motif of N (Ser180Ile, Ser183Tyr, Ser188Leu, Ser190Asn, Ser193Ile, Ser194Leu, Arg195Lys, Ser197Leu, Ser202Asn
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
8Discussion: It was not surprising to observe the triple site mutation 28881-28883 GGG>AAC (
Discussion: Few strains from Europe and North America since February 2020 have shown the emergence of mutations like 3037C>T (F106F, NSP3), 23403A>G (D614G), and 28881-28883GGG>AAC (R203K and G204R, N) in the SARS-CoV-2 genome harboring the 14408C>T (P323L) mutation within the RdRP gene, suggesting a probable association or coexistence of 14408C>T (P323L) and the emerging higher number of novel point mutations compared to viral genomes from Asia.
Abstract: Previously reported mutations including D614G in S gene,
Result: N gene mutations idenfied in this study (S194L, R203K, and G204R) are located in the region 180-247, which is suggested to be a flexible linker region that lacks organized structure.
Result: Oklahoma-ADDL-4, carried a non-synonymous mutation S194L while Oklahoma-ADDL 2,3,5 carried R203K and G204R.
Table: G204R
Figure: (A) The mutations S194L, R203K, and G204R are located in the highly conserved linker region as indicated in panel.
SARS_CoV_2 mutation literature information.
PMID: 
2020
PloS one
Browser Board
Co-occurred Entities
Filtrator
ViMRT