literature

SARS_CoV_2 mutation literature information.

Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies.

PMID: 35215820 2022 Viruses

Result: In total, five mutations (A67V, E406E/G, D427D/Y, Q493R and G1204G/E) appeared in the S gene in samples taken from four patients (P2, P3, P5 and P6), three of whom were receiving bamlanivimab therapy (one as a monotherapy and two in combination) and one a combination of casirivimab/imdevimab.

Discussion: However, no rise of the viral load was observed between the two samples, and the patient recovered from COVID-19, suggesting a limited impact of this mutation on immune escape and resistance, similar to the G1204G/E mutation selected with bamlanivimab/etesevimab.

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