Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.
PMID: 32451533
2020
American journal of clinical pathology
Discussion: A study examining the transmission and evolution of SARS-CoV-2 in cruise quarantine suggests that the G11083T mutation can be transmitted via RNA recombination.
Discussion: It has been suggested that the G11083T mutation is more common in regions (Italy and Brazil) with higher fatality rates.
Discussion: Linkage disequilibrium analysis suggests that RNA recombination with a G11083T mutation may contribute to the increase of mutations among the viral progeny.
Discussion: More studies are needed to determine if G11083T, or other mutations detected in this case, may increase the fitness of the carrier virus as a benefit allele in the future.
Discussion: The viral RNA from our cases also had G11083T mutation that to date has been described in only 2% (13/648) of the A2a clad
Result: G11083T variation (reported previously by van Dorp et al., 2020) causing L36F exchange was present on Nsp6 gene region that is known with its role in inducing vesicles located around the microtubule regulation centre and ensuring membrane proliferation (Angelini et al., 2013).
Result: It has been observed that 8 of these 11 variations; C1059T, G11083T, C14408T, A23403G, G25563T, G28881A, G28882A, and G28883C cause amino acid substitutions.
Result: The other 3 variations, C1059T, PMID: 32595354
2020
Turkish journal of biology
Discussion: G11083T is the most common one among such sites across different countries and sequencing technologies, which might be an indicator of this position being either a site for frequent mutation or an arte
Discussion: Both C8782T and G11083T mutations were found to be mostly present in Oceania isolates, where followed by North America and Europe subsequently (Pachetti et al., 2020).
Discussion: When we consider the mutations in ORF1ab, nucleotide substitutions of C884T, G1397A, C3037T, G8653T, G11083T, C14408T, and C18877T were seen in more than 15% (11/62) of the samples.
Geographic and Genomic Distribution of SARS-CoV-2 Mutations.
Result: In Asia, while the most common mutation was G11083T for samples sequenced between December 2019 and March 2020, recent sequencing efforts have highlighted a current profile similar to those of the other continents (Figure 3A).
Table: G11083T
Characterizing SARS-CoV-2 mutations in the United States.
Result: In Cluster A, B, C, and D, the co-mutations with the highest number of descendants are [8782C>T, 18060C>T, 28144T>C], [241C>T, 3037C>T, 14408C>T, 23403A>G], [11083G>T], and [3037C>T, 14408C>T], respectively.
Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR(-/-) mice.
Decoding Asymptomatic COVID-19 Infection and Transmission.
PMID: 33179934
2020
The journal of physical chemistry letters
Abstract: By analyzing the distribution of 11083G>T in various countries, we unveil that 11083G>T may correlate with the hypotoxicity of SARS-CoV-2.
Abstract: Moreover, we show a global decaying tendency of the 11083G>T mutation ratio indicating that 11083G>T hinders the SARS-CoV-2 transmission capacity.
Abstract: On the basis of the genotyping of 75775 SARS-CoV-2 genome isolates, we reveal that asymptomatic infection is linked to SARS-CoV-2 11083G>T mutation (i.e., L37F at nonstructure protein 6 (NSP6)).
In
Introduction: 11083G>T was found in Vietnam 2 months after the first confirmed cases, which resulted in a low 11083G>T mutation ratio.
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
SARS_CoV_2 mutation literature information.
PMID: 
2020
American journal of clinical pathology
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