Result: All B.6 strains within this group contained four additional genetic variations; C6312A, C13730T, C23929T, and C28311T in addition to G11083T mutation.
Result: All strains within this B.2/B.6 lineage shared genetic variation G11083T, encoded for amino acid changes from leucine to phenylalanine at position 37 of nsp6 in ORF1ab.
Result: The G11083T and G26144T were genetic markers for the assignment of GISAID Clade V.
Table: G11083T
SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity.
Conclusion: Here, we performed genome-wide association analyses on all SARS-CoV-2 genomes in the GISAID database, and found that a mutation at genomic position 11 083, namely the 11083G>T mutation, located in the coding region of non-structural protein 6, is significantly associated with asymptomatic COVID-19, adjusted for various confounders and covariates, including virus phylogenetic relatedness, patient age, gender and country.
Genomic Variations in SARS-CoV-2 Genomes From Gujarat: Underlying Role of Variants in Disease Epidemiology.
Result: Mutations (C241T, C3037T, A23403G, and C14408T) were dominant with frequency (>60%) in all the genomes (Gujarat, India, and global), whereas mutations (G11083T, C13730T, C28311T, C6312A, C313T, C5700A, G29868A, and C23929T) dominated (>19%) in the Indian genomes compared with the Gujarat and global genomes.
Result: Mutations G11083T and C6312A lie in the region of Orf1a encoding Nsp6, whereas mutat
Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.
Result: A23403G and C14408T were observed at higher frequencies (>50%) in all the genomes, while G25563T, C13730T, G11083T C6312A, C241T, C3037T, G11083T, C13730T, C28311T, C6312A and C23929T mutations were predominated (>24% frequency) in Indian genomes (Additional File1).
Result: Examining the variants from the O clade isolates observed the most frequent variant as G11083T (46.7%), C28311T (22.7%), and C
Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan.
Result: Furthermore, Gilgit1/2020 (EPI_ISL_417444) strain had similar variations at 241C>T and 11083G>T in ORF1ab while KP-RMI-01/2020 (EPI_ISL_632908) showed a single change (11083G>T in ORF1ab) (Fig 3A).
Result: The KPK-KUST-SJTU/2020 contained nucleotide changes in ORF1ab (2416C>T, 8371G>T, 11083G>T), S-gene (22477C>T) and ORF3a (25563G>T).
Result: We have analyzed the genome-wide single-nucleotide polymorphisms (SNPs) and found nine common nucleotide variations (241C>T<
Global and local mutations in Bangladeshi SARS-CoV-2 genomes.
Introduction: Three other mutations namely C14408T (ORF1b), C241T (5' UTR), C3037T (ORF1a) are reported to be common and coexisting in the same genome, while G11083T has been found mostly in Asian countries.
Whole genome analysis of more than 10 000 SARS-CoV-2 virus unveils global genetic diversity and target region of NSP6.
Discussion: In addition to these mutation points, the most frequent (in more than 10% of virus population) and common mutation points between global excluding India and India are G11083T (L37F), T19557A (F506L), A19558G (S507G) and G25563T (Q57H) in NSP6, Exon and ORF3a respectively.
Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines.
Result: One synonymous (23929C>T in the S gene) and four nonsynonymous mutations (6312 C>A{T2016N}, 11083G>T{L3606F}, 13730C>T{A4489V} in ORF1ab; 28311C>T{P13L} in the N gene) were observed in the sample (OUMRK1090/2020) collected from patient with travel history to UAE.
Result: One synonymous (23929C>T in the S gene) and four nonsynonymous mutations (6312 C>T{
SARS_CoV_2 mutation literature information.
PMID: 
2021
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