Conclusion: Here, we performed genome-wide association analyses on all SARS-CoV-2 genomes in the GISAID database, and found that a mutation at genomic position 11 083, namely the 11083G>T mutation, located in the coding region of non-structural protein 6, is significantly associated with asymptomatic COVID-19, adjusted for various confounders and covariates, including virus phylogenetic relatedness, patient age, gender and country.
Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.
PMID: 34540148
2021
Iranian journal of microbiology
Table: G11083T
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Discussion: Interestingly, the signature of another super spreader, which was less encountered in European genomes, namely the change in 11083 G > T was present in two of our samples.
Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine.
PMID: 34248221
2021
Bulletin of the World Health Organization
Abstract: CONCLUSION: The findings indicate that the 11083G > T mutation of SARS-CoV-2 spread during shipboard quarantine and arose through de novo RNA recombination under positive selection pressure.
Abstract: FINDINGS: The SARS-CoV-2 outbreak in the cruise most likely originated from either a single person infected with a virus variant identical to the WIV04 isolates, or simultaneously with another primary case infected with a virus containing the 11083G > T mutation.
Abstract: Linkage disequilibrium analysis confirmed that ribonucleic acid (RNA) recombination with the11083G > T mutation also contributed to the increase of mutations among the viral progeny.
Result: Due to 11083G > T mutation, the clustering of taxa on viral phylogenies was obvious with spatially structured host population between all these subgroups (50%; 14/2
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Result: The group C featured by SNVs G11083T and G26144T disappeared, being detected in only 53 genomes after June 2020.
Result: There were another three SNVs specific to males with a strong connection to the mortality, G11083T (nsp6:L37F), G28878A (ORF9:S202N<
Discussion: Although the majority of groups A and C SNVs were observed to be mutually exclusively with each other before June 2020, 95% of genomes harboring the representative SNV in the group C, G11083T (ORF1ab:L3606F), also carried group A SNVs after June 2020, confirming the ruling role of group A in current SARS-CoV-2 genomes.
Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis.
PMID: 34154921
2021
Journal of infection and chemotherapy
Table: G11083T
Shedding of Viable Virus in Asymptomatic SARS-CoV-2 Carriers.
Result: All SARS-CoV-2 strains belonged to clade 19A identified by Nextstrain, and they harbored a single nucleotide mutation at position 11083 (G11083T transversion), leading to a nonsynonymous amino acid substitution (Leu37Phe) in nonstructural protein 6 (nsp6), as previously described from the Diamond Princess outbreak event.
New framework for recombination and adaptive evolution analysis with application to the novel coronavirus SARS-CoV-2.
Discussion: There are other high-frequency mutations widely distributed on the genome whose effects are yet to be elucidated (for example, G11083T between Cluster 1 and Cluster 2 as well as C1059T and G15583T between Cluster 4 and Cluster 8).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Microbial genomics
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