Result: Analysis of the variant frequencies found in the respective samples showed a ~60% variant frequency for the G11083T substitution in the ORF1ab after isolation.
Rapid SARS-CoV-2 Intra-Host and Within-Household Emergence of Novel Haplotypes.
5Result: According to the phylogenetic and MSN reconstructions, only one sequence, ""VO_SR_65"" (haplotype G11083T, G26144T, C22088T), shares a private mutation with a Polish sequence, EPI_ISL_455452 (haplotypes C4338T, T9743C, G11083T, G26144T, and C22088T)."
Abstract: Here we report the analysis of 87 viral genomes, which revealed that the unique ancestor haplotype introduced in Vo' belongs to lineage B, carrying the mutations G11083T and G26144T.
Result: All the viral sequences were characterized by two mutations, G11083T and G26144T (fro
Genomic Characterization of SARS-CoV2 from Peshawar Pakistan Using Next-Generation Sequencing.
Result: Out of total 10 variants, the following 5 mutations were identified in the ORF1ab region: 1139A > G (codons AAG to GAG, missense mutation), 2144G > T (codons GTC to TTC, missense mutation), 11083G > T (codons TTG to TTT, missense mutation), 13730C > T (codons: GCT to GTT, missense mutation), and 6312 C > A (codons ACA to AAA, missense mutation).
SARS-CoV-2 outbreak in Iran: The dynamics of the epidemic and evidence on two independent introductions.
PMID: 33835709
2022
Transboundary and emerging diseases
Result: G11083T is one of the most frequent mutations observed in Asia from December 2019 to March 2020 (Koyama et al., 2020; Mercatelli and Giorgi, 2020) and, not surprisingly, is observed mostly along with B.4 substitutions.
Result: Notably, just four variants, namely G1397A, T28688C, G29742T and G11083T, contributed to >70% of samples; comprising the common co-occurrence of variants, [G1397A-T28688C-G29742T] in B.4 lineage.
Result: Remarkably, co-occurrence of D614G mutation with B.4 [G1397A-T28688C-
Table: G11083T
Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.
PMID: 34540148
2021
Iranian journal of microbiology
Table: G11083T
Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity.
Discussion: Although the clinical implications of these variants remain unclear, 1 study noted that the 11083G>T variant was associated with asymptomatic transmission.
Discussion: Clade V is hallmarked by 2 nonsynonymous variants, 11083G>T (L37F ORF1ab) and 26144G>T (G251V ORF3a), leading to alterations in the NSP6 and NS3 proteins, respectively.
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Discussion: Interestingly, the signature of another super spreader, which was less encountered in European genomes, namely the change in 11083 G > T was present in two of our samples.
Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine.
PMID: 34248221
2021
Bulletin of the World Health Organization
Abstract: CONCLUSION: The findings indicate that the 11083G > T mutation of SARS-CoV-2 spread during shipboard quarantine and arose through de novo RNA recombination under positive selection pressure.
Abstract: FINDINGS: The SARS-CoV-2 outbreak in the cruise most likely originated from either a single person infected with a virus variant identical to the WIV04 isolates, or simultaneously with another primary case infected with a virus containing the 11083G > T mutation.
Abstract: Linkage disequilibrium analysis confirmed that ribonucleic acid (RNA) recombination with the11083G > T mutation also contributed to the increase of mutations among the viral progeny.
Result: Due to 11083G > T mutation, the clustering of taxa on viral phylogenies was obvious with spatially structured host population between all these subgroups (50%; 14/2
Shedding of Viable Virus in Asymptomatic SARS-CoV-2 Carriers.
Result: All SARS-CoV-2 strains belonged to clade 19A identified by Nextstrain, and they harbored a single nucleotide mutation at position 11083 (G11083T transversion), leading to a nonsynonymous amino acid substitution (Leu37Phe) in nonstructural protein 6 (nsp6), as previously described from the Diamond Princess outbreak event.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Nature communications
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