literature

SARS_CoV_2 mutation literature information.

An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms.

PMID: 34767598 2021 PLoS pathogens

Abstract: While sharing the N501T mutation which is common in mink, the Utah strains did not share other spike RBD mutations Y453F and F486L found in nearly all mink from the United States.

Discussion: The Utah mink did not share other spike RBD mutations Y453F and F486L, which are common in U.S.

Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach.

PMID: 34720581 2021 Bioinformatics and biology insights

Result: We also analyzed the effect of 27 missense variants of SARS-CoV-2 spike protein (RBD) on the binding interaction of spike protein with ACE2 and observed that L452Q, T478K, L455F, F456L, S459F, A475V, N439K, L452R, T470N, E484D, E484A, E484K, E484Q, F486L, S494P, S494L, N501T,

PMID: 34649620 2021 Genome medicine

Abstract: The comprehensive escape mutation map not only confirms the widely circulating strains carrying important immune escape RBD mutations such as K417N, E484K, and L452R, but also facilitates the discovery of new immune escape-enabling mutations such as F486L, N450K, F490S, and R346S.

Result: Markedly, K417N, F486L, L452R, E484K, and R346S resulted in resistance to at least six plasma samples, as the NAb titers were approximately 2-4 times lower than those for the wildtype, indicating that NAbs targeting these key residues were e

The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America.

PMID: 34642638 2021 ArXiv

Introduction: Later on, we have provided a list of most likely vaccine escape RBD mutations with high frequency, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.

Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies.

PMID: 34642465 2021 Scientific reports

Result: The mutagenesis results obtained by mutating these three viral spike amino acids into the report

Result: led to the following list of naturally occurring mutations at the SARS-CoV-2 spike protein residues contacting the LY-CoV555 mAb: E484A/D/G/K/Q/R/V, Q493H/K/L/R, S494A/P/R/T, L452M/Q/R, Y449D/F/H/N/S, T470A/I/K/N, V483A/F/G/I/L, F486I/L/S, Y489C/F/H/S, and F490L/S/V/Y.

Review of the mechanisms of SARS-CoV-2 evolution and transmission.

PMID: 34545334 2021 ArXiv

Introduction: A list of vaccine-escape (vaccine-breakthrough) mutations was tabulated in our early work, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.

Introduction: Many of these co-mutation sets involve vaccine-escape mutations predicted in our early work: S494P, Q493L, K417N, F490S, F486L, R403K,

PMID: 34464596 2021 Immunity

Discussion: Although mutations such as these that abrogate 2C08 binding currently are rare among clinical isolates, viruses carrying the F486L mutation have been isolated from farmed mink and could be transmitted to humans.

Revealing the Threat of Emerging SARS-CoV-2 Mutations to Antibody Therapies.

PMID: 34273397 2021 Journal of molecular biology

Abstract: We unveil, for the first time, that high-frequency mutations R346K/S, N439K, G446V, L455F, V483F/A, F486L, F490L/S, Q493L, and S494P might compromise some of mAbs in clinical trials.

Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants.

PMID: 34224110 2021 Virologica Sinica

Introduction: SARS-CoV-2 variants isolated from minks and mouse harboring mutations G261D, A262S, L452M, Y453F, F486L, Q498H and N501T may cause potential cross-species transmission that worth closely monitor (Thomson et al.; Yao et al.).

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants' interaction with ACE2 to understand the binding affinity and stability.

PMID: 34217923 2021 Virology

Table: F486L

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