Inhibitor screening using microarray identifies the high capacity of neutralizing antibodies to Spike variants in SARS-CoV-2 infection and vaccination.
Result: Interestingly, 8/10 (80%) mutations that decreased the ability of the S protein to bind ACE2 (G446V, F456E, G485S, F486S, N487R, F490L, P499R, Y505C) are located at the RBD-ACE2 interaction interface (Figure 2E).
Result: Moreover, F456E and N487R had the weakest ACE2 binding affinities.
Result: Notably, structural analyses show that 5 escape mutations (K417N/E484K/N501Y, G446V, F456E
SARS_CoV_2 mutation literature information.
PMID: 
2022
Theranostics
Browser Board
Co-occurred Entities
Filtrator