literature

SARS_CoV_2 mutation literature information.

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.

PMID: 34484190 2021 Frontiers in immunology

Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,

PMID: 34488546 2021 Expert review of vaccines

Introduction: P681R/P681H also exists in several variants under investigation in the United Kingdom, including A.23.1/E484K, B.1.1.7, and B1.318.

Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and high-frequency mutation N501Y in different levels of control measures.

PMID: 34493762 2021 Scientific reports

Result: Delta69-70, N501Y, and E484K, all present in the second group.

Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid and Potential Utility for SARS-CoV-2 Detection.

PMID: 34494022 2021 bioRxiv

Abstract: E-beacon prepared for the E484K variant of SARS-CoV-2 functioned with similar sensitivity.

Introduction: A second E-beacon was prepared for detecting the E484K mutation, which is present in certain alpha and all beta and gamma strains of SARS-CoV-2.

Introduction: Here Eb.19 (E484K) was mixed with either E484K target oligo (Figure 3C, top trace), with random oligonucleotide, E484 (WT) or an oligo corresponding to E484Q of the SARS-CoV-2 Kappa variant.

A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo.

PMID: 34495697 2021 Journal of virology

Introduction: Using this strategy, we have successfully rescued Venus-and mCherry-expressing rSARS-CoV-2 USA/WA1/2020 (WA-1) and a new rSARS-CoV-2 strain expressing mCherry and containing mutations K417N, E484K, and N501Y present in the receptor binding domain (RBD) of the viral spike (S) glycoprotein of the South Africa (SA) B.1.351 (beta [beta]) VoC.

Result: Towards this objective, we generated an rSARS-CoV-2 containing the K417N, E484K, and N501Y mutations found in the S RBD of the SA strain of SARS-CoV-2 and expressing also mCherry, referred to as rSARS-CoV-2 mCh

SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levels.

PMID: 34495709 2021 Journal of clinical microbiology

Abstract: Of the 200 samples belonging to the B.1.575 lineage, 194 (97%) corresponded to the B.1.575.2 sublineage, which was related to the presence of the E484K mutation.

Abstract: We report the emergence and spread of a new SARS-CoV-2 variant within the B.1.575 lineage, containing the E484K mutation in the spike protein (named B.1.575.2), in a region in northern Spain in May and June 2021.

Method: At that time, we customized the TaqMan assay to detect SARS-CoV-2 spike protein with the N501Y, E484K, K417N, and K417T mutations.

Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2).

PMID: 34495817 2021 Journal of biomolecular structure & dynamics

Figure: (a) Native (control) spike (red) and E484K variant (blue), (b) Native spike (red) and N501Y variant (yellow), (c) Native spike (red) and multiple (K417N + E484K + N501Y) spike variant (green).

Figure: (a) Native spike (red) and E484K (blue) variant, (b) Native spike (red) and N501Y variant (yellow), (c) Native spike and multiple (K417N + E484K + N501Y) spike v

PMID: 34499599 2021 Emerging infectious diseases

Introduction:

Introduction: E484K causes resistance to many class 2 RBD-directed antibodies, including bamlanivimab.

Introduction: E484K has been additionally reported in 1 of 6,011 B.1.617.1 (Kappa variant) sequences.

Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 Affinity.

PMID: 34502041 2021 International journal of molecular sciences

Introduction: Further, the B.1.618 (triple mutant), recently detected in the four Indian states (Maharashtra, Delhi, West Bengal and Chhattisgarh), has been characterized by the deletion of Tyr145 and His146 as well as E484K and D614G mutation in the spike protein (accessed on 10 July 2021).

Introduction: In October 2020, B.1.351 (Beta variant) was detected in the South African population, which could infect more younger people and had three primary mutations in the RBD of spike protein, namely, N501Y, K417N and E484K.

Introduction: Similarly, the lineage P.1 (Gamma variant) detected in January 2021 in the Brazilian population had three mutations of concern in spike&nbs

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Discussion: However, some variants that have destabilized the protein with increased flexibility (e.g., E484K, K417 N, E484Q, Q675P, and Q675H) might impact the virus's ability to escape the antibodies neutralization by changing the antigenicity drift of the protein 3D structure; this is in agreement with a previous study.

Discussion: Moreover, the results from DynaMut thermodynamic predictions indicated 10 variants had destabilized the spike protein (e.g., E484K, K417 N, V1176F, E484Q, Q675P, and Q675H), two of them, the E484K and the

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