Discussion: There was another sequence sampled from Shiraz in Oct 2020 that contained five specific mutations (D138Y, D614G, E484K, K417T, N501Y) as indicator of the Gamma variant (GR/501Y.V3 (P.1+P.1.x)) and was clustered along with the representative Gamma variant spike sequence in phylogenetic tree.
Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid.
Abstract: E-beacon prepared for the SARS-CoV-2 E484K variant functioned with similar sensitivity.
E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody.
PMID: 34915409
2022
International immunopharmacology
Discussion: However, the E484K mutation diminishes its interaction with Bamlanivimab in vitro.
Discussion: On the other hand, how the E484K mutation alters the ACE2 recognition is yet to be understood at the structural level.
Discussion: Results obtained from this study provide crucial insight into the efficacy of therapeutic mAbs on SARS-CoV2 variants harboring the E484K
Discussion: recently evaluated the susceptibility of the 28 pseudoviruses expressing many spike single and multiple variations to neutralization by 12 mAbs (11 of them are anti-RBD) and observed that the E484K mutation is resistant to class II mAbs, while in combination with K417N and N501Y it showed resistance to class I and II mAbs.
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.
Result: A large group of mAbs (Beta-6, -10, -23, -24, -30, -40, -54, -55, -56) showed good neutralization of Alpha, Beta, Gamma, and Alpha+ viruses, with either reduced or completely absent neutralization of Victoria, B.1.525 (E484K), and Delta viruses (Figure 2B).
Result: Four representative mAbs from different epitope classes were selected: Beta-20, which recognizes the K417N/T mutation and can potently neutralize Beta and to a lesser extent Gamma, Beta-24, which is specific to the N501Y mutation present in Alpha, Beta, and Gamma, Beta-26, which recognizes the E484K mutation found in Beta and Gamma, and Beta-27, the IgVH3-53 fully cross-reactive mAb, which neutralizes all variants similarly.
Result: MAb Beta-26 requires the Beta E484K mutation f
Table: E484K
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine.
PMID: 34929375
2022
Travel medicine and infectious disease
Introduction: The B.1.1.7 is reported to be more infectious with higher spreading rate and increased binding affinity to ACE2 in particular due to N501Y, compared with other mutations such as E484K.
Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia.
PMID: 34933126
2022
Infection, genetics and evolution
Conclusion: Also, we found important mutations such as E484K<
Result: The mutations p.Lys1191Asp (K1191D), p.Glu484Lys (E484K), p.Leu18Phe (L18F), p.Pro26Ser (P26S), p.His655Tyr (H655Y), p.Asp614Gly (D614G), that along with other nucleotide substitutions constitute some of the VOC and VOI, were also identified, but not necessarily defining a complete lineage of interest.
Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.
PMID: 34848355
2022
Infection, genetics and evolution
Introduction: Emerging SARS-CoV-2 variants in early 2021, including B.1.1.7/B.1.1.7 + E484K lineage (United Kingdom), B.1.351 lineage (South Africa), P.1 lineage (Brazil), and B.1.427/B.1.429 lineage (California) has rapidly become dominant in domestic and arousing global concerns.
Table: E484K
Discussion: Notably, sub-haplotypes 2A_3 and 2B_1 had the mutations at K417T, and E484K in the spike was a small proportion in the high partly vaccinated rate group in May 2021, which was found to decrease neutralization of human immune serum and cause severe disease even in patients that have been previously infected.
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.
Introduction: E484K is thought to be responsible for the ability of Beta to escape neutralization by plasma from convalescent individuals.
Introduction: Beta has nine mutations in S, including N501Y, and two in the S receptor-binding domain (RBD), K417N and E484K.
A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).
Abstract: But some mutations of concern, such as E484K from B.1.351 and P.1 lineages are currently under monitoring, together with those observed in the receptor-binding domain or N-terminal domain, such as L452R and T478K from B.1.617.2 lineage.
Result: Other mutations of concern such as Discussion: Nonetheless, the prevalence of E484K mutation among other lineages also increased in many countries due to its benefits for SARS-CoV-2, not only for its major transmissibility, but also evading antibody neutralization from host immune response.
Discussion: The same activity is described for E484K substitution, shared by B.1.351 and P.1 lineages, and reported during the initial weeks of the third wave in our study, as in other European regions.
Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France.
Abstract: Thus, the spike Q677H substitution should be considered as another example of convergent evolution, as it is the case of spike substitutions L18F, E484K, L452R, and N501Y which also independently appeared in various lineages.
Introduction: The variants recently considered to be of greatest concern are those carrying amino acid substitutions N501Y and/or E484K within the spike protein, as they have increased affinity for the ACE2 cellular receptor, decreased sensitivity to neutralising antibodies, and may escape the immune responses elicited by the vaccines currently used in Western countries.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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