Introduction: In contrast, the single mutation in the
RBD (
E484K) swaps the charge of the sidechain, which would significantly alter the electrostatic complementarity of antibody binding to this region.
Introduction: In the
RBD, the possibility to escape is limited and the mutation
E484K that we found is one of the most frequent mutations to escape monoclonal antibodies and among the most common
RBD mutations described in experimental settings as well as in natural isolates posted in the GISAD database.
Introduction: The ability of the virus to adapt to the host immune system was also observed in clinical settings where an immunocompromised
COVID-19 patient, after 154 days of infection, presented different variants of the virus including the
SARS_CoV_2 mutation literature information.
PMID: 
2021
Chemical science
