Method: In addition, three separate assays were designed to detect spike mutations and wild type, E484K versus E484E, L452R versus L452L, and K417N versus K417K.
Table: E484E
SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation.
PMID: 33905892
2021
Infection, genetics and evolution
Result: In addition, no structural variants in the receptor-binding domain (RBD) of the Spike protein (N439K, T481I, V483A, E484E, N501Y nor G476S) were identified.
Emergence of the E484K mutation in SARS-COV-2-infected immunocompromised patients treated with bamlanivimab in Germany.
PMID: 34278371
2021
The Lancet regional health. Europe
Result: 1E) was a caucasian male in his late sixties with B-cell chronic leukemia (CLL) stage Binet C who had persistent positive SARS-CoV-2 RT-qPCR (3 12 x 107copies/mL, strain B.1.258, harbouring E484E) 44 days after the first positive SARS-CoV-2 RT-qPCR in December 2020 before scheduled initiation of CLL treatment with ibrutinib.
Result: Admission screening (d1) revealed a SARS-CoV-2 infection with 2 22 x 107 copies/ml (strain B.1.1, harbouring E484E).
Result: At admission, her SARS-CoV-2 viral load was 9 36 x 106 (strain B.1.160, harbouring E484E).
Result: On day 74, SARS-CoV-2 RT-qPCR was positive again on a nasopharyngeal swab with 2 0 x 105 copies/mL (stra
Characterization of SARS-CoV-2 East Java isolate, Indonesia.
Conclusion: It showed a typical B1.1.7 variant on the first sample (April 13th); double populations: K417K/N, E484E/K and Q493Q/R on the 2nd sample (28th April), and E484K and K417N on the 3rd sample (May 8th).
Figure: No amplification for the negative control; wild type samples (E484E) segregate on the low right; E484K samples segregate at the top; sample collected from our patient is observed in an intermediate location between wild type samples and E484K samples.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Microbiology spectrum
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