literature

SARS_CoV_2 mutation literature information.

Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction.

PMID: 35219552 2022 Diagnostic microbiology and infectious disease

Table: D839Y

Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal.

PMID: 35083576 2022 Archives of virology

Discussion: In this study, the VSV system was used to construct pseudoviruses harboring high-frequency SARS-CoV-2 mutations circulating in Portugal, including D614G, A222V+

Discussion: Interestingly, for the majority of high-frequency mutant viruses circulating in Portugal (i.e., A222V+D614G, B.1.1.7, D839Y+D614G, P1162R+D614G+A222V, S477N+D614G, and L176F+D614G, but not B.1.1.7 and S477N+D614G), immune escape from the mAbs used in this study was not observed.

SARS-CoV-2 phase I transmission and mutability linked to the interplay of climatic variables: a global observation on the pandemic spread.

PMID: 35028838 2022 Environmental science and pollution research international

Introduction: Apart from this, L5F was also observed in 37 countries; Q239K, V483A, and D839Y/N/E in Europe; G476S and V483A in the USA; and P1263L in the UK.

SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring.

PMID: 33676232 2021 Biochemical and biophysical research communications

Result: Eleven spike mutations were not found associated with ORF8 variants: L8V/W, N234Q, Q239K, L452R, A475V, G476S, V483A, F490L, V615I/F, A831V and D839Y/N/E.

Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.

PMID: 35017872 2021 Journal of global infectious diseases

Discussion: Though D614G is associated with increased infectivity, mutations such as Q239R, T719I, T719S, D839Y, P1263 L, mutations in RBD such as I434K and P521S, and D614G+Q675H are reported to have decreased infectivity.

Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach.

PMID: 34346317 2021 Computers in biology and medicine

Result: As a meta result, i-stable predicted, out of 62 nonsynonymous mutations, 40 nonsynonymous mutations (L5F, L8V, L8W, L18F, L54F, T76I, V120I, D138Y, Y145H, M153T, F157S, L176F, G181V, D215H, A262T, V367F, G476S, V483A, L611F, Q675H, Table: D839Y

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: D839Y

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Table: D839Y

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 33976134 2021 Nature communications

Result: Another three are in moderately conserved contexts (V367F, D839Y/N/E, D936Y/H) less likely to be functional, and eight lie in repeatedly-altered amino acids in poorly conserved regions and are more likely to be neutral.

D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect.

PMID: 33946306 2021 Molecules (Basel, Switzerland)

Discussion: It is worth noticing that, for other frequent variants included in the same study, such as L5F and D839Y, infectivity was virtually unchanged.

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