Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.
PMID: 34606987
2021
Infection, genetics and evolution
Abstract: Comparative analyses of the viral sequences reveal the prevalence P4715L and D614G mutations as the most recurrent and concurrent in Africa (97.20%), Europe (89.83%) and moderately in Asia (61.60%).
Abstract: High recurrent mutations, namely: T265I in non-structural protein 2 (nsp2), L3606F in nsp6, P4715L in RNA-dependent RNA polymerase (RdRp), D614G in spike glycoprotein, R203K and G204R in nucleocapsid phosphoprotein and Q57H in PMID: 34607452
2021
mBio
Introduction: 2B04 exhibited an ~50% reduction in neutralization of Q677H relative to WT and of Q677H/D614G relative to D614G.
Introduction: Again, all variants, including those containing Q677H, showed decreased neutralization compared with D614G.
Introduction: In examining the infectivity of the lentiviral pseudotypes (see Text S1 in the supplemental material), all D614G-containing variants showed enhanced infectivity, whereas E484K exhibited decreased infectivity (29%, P < 0.01) and B.1.525 showed an increase (41%, P < 0.01) compared to D614G.
Introduction: In particular, B.1.525 and E484K/Q67
Molecular switches regulating the potency and immune evasiveness of SARS-CoV-2 spike protein.
Discussion: Several months in the pandemic, a D614G mutation allowed more SARS-CoV-2 spike molecules to open up, a sign that the virus was gaining more potency.
Distant residues modulate conformational opening in SARS-CoV-2 spike protein.
8Discussion: However, both experimental and computer simulation studies have already established that D614G, A570D, and a few other mutations transform the dynamics of the RBD and favor an ""up"" state."
8Discussion: In vitro experiments also established that the single point mutation D614G is capable of altering the ""down"" to ""up"" conformational dynami
Discussion: Another mutation, A570V, was observed within our predicted residues, but did not yet become as widespread as D614G, likely because it did not have substantial evolutionary advantage.
Discussion: However, we do show that the dihedral angle preference, interaction energy, and hydrogen bonding pattern of concerned residues change significantly due to a D614G mutation.
Spread of Mink SARS-CoV-2 Variants in Humans: A Model of Sarbecovirus Interspecies Evolution.
Abstract: Mink-selected SARS-CoV-2 variants carrying the Y453F/D614G mutations display an increased affinity for human ACE2 and can escape neutralization by one monoclonal antibody.
Introduction: The D614G mutation was previously reported as a variant having emerged in humans and conferring higher affinity for the ACE2 receptor.
Introduction: The D614G mutation which became dominant in human SARS-CoV-2 isolates, was reported to increase viral infectivity.
Introduction: This D614G<
Discussion: Of interest is the distribution of the mink SARS-CoV-2 spike sequences within Group 4 into two populations, one bearing only the Y453F and D614G mutations, and the second accumulating many other mutations.
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
Discussion: Although a significant transmission advantage of D614G is found, we notice that the proportion of 614G variant generally increased, while the reproduction number series decreased in March and then remained constant.
Discussion: Although some recent studies indicate that the D614G mutation is unlikely to undermine the neutralization from current SARS-CoV-2 vaccine candidates, there are also other studies suggest the concerns should be raised oppositely.
Discussion: Although the variants carrying D614G substitution might be introduced to California from aboard during the first few months of pandemic, the observed changes in SARS-CoV-2 mutations (pt) were likely due to the spread of virus locally after the implementation of strict travel-ban measurements.
Discussion: Consistent evidences of the transmission advantage of D614G s
Characterization of SARS-CoV-2 East Java isolate, Indonesia.
Introduction: It is reported that at the population level, there is relatively insufficient herd immunity to drive significant mutation, and there are several spike mutations that increase virus transmission without changes in clinical significance such as D614G.
Table: D614G
Discussion: Thus, the analysis of the SARS-CoV-2 spike gene shows the mutation of D614G that increases SARS-CoV-2 infectivity, whereas the E484D mutation was correlated with human immune serum neutralization resistance.
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
Introduction: At the beginning of April 2020, a variant with the spike protein (S-protein) D614G mutation replaced the original SARS-CoV-2 strain in many areas of the world, as the mutation appears to improve the binding efficiency between the receptor binding domain (RBD) with the angiotensin-converting enzyme 2 (ACE2) receptor.
Introduction: In September 2020, the B.1.1.7 lineage emerged as a variant of concern in the United Kingdom (UK), subsequently termed the alpha variant, with 9 spike protein mutations (del69/70HV, del144Y, N501Y, A570D, D614G, P681
Table: D614G
Cross-Neutralizing Activity Against SARS-CoV-2 Variants in COVID-19 Patients: Comparison of 4 Waves of the Pandemic in Japan.
PMID: 34631915
2021
Open forum infectious diseases
Introduction: By the beginning of April 2020, a variant bearing a D614G mutation with evidence of increased infectivity had become dominant.
Introduction: In addition to D614G and several mutations in other areas of the genome, B.1.1.7 bears 8 mutations in the spike gene including deletions in the N-terminal domain ( H69/ V70, 144) and amino acid substitutions in the receptor binding domain (N501Y).
Introduction: In this study, we investigated the neutralizing potency of serum from patients infected during the first to fourth waves of the pandemic against the SARS-CoV-2 variants D614G, B.1.1.7, B.1.351, and P1, using authentic virus.
Introduction: SARS-CoV-2 genome surveillance has revealed that D614G<
Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates.
PMID: 34633892
2021
Journal of biomolecular structure & dynamics
Abstract: Most of the SARS-CoV-2 isolates belongs to the G clade and showed a large occurrence of D614G, N501Y and L18F substitutions.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Infection, genetics and evolution
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