Result: Among them, 3 mutations are synonymous ones (i.e., 3037C>T-(F106F), 8782C>T-(S76S), and 18060C>T-(L7L)) and 8 mutations are the missense mutations (i.e., 14408C>T-(P323L), 23403A>G-(D614G), 25563G>T-(Q57H), 1059C>T-(T85I), 28144T>C-(L84S), 17858A>G-(Y541C), 17747C>T-(P504L), and
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
Introduction: 3B), but further analyses would be required to assess whether the D614G mutation has an effect on the way the S protein changes its conformation after interaction with ACE2.
Introduction: A comparison against the previous set of genomes collected for our phylogenetic and molecular dating analysis revealed that for samples submitted during the period from March 17-30, 2020, the D614G clade became increasingly prevalent worldwide, expanding from 22 to 42 countries.
Introduction: Accordingly, it was not possible to draw any conclusions regarding the clinical phenotype of the D614G clade and there is no evidence at this time to suggest this clade is associated with any differences in disease phenotype.
Introduction: Although the mutation appears to be clade-specific, we noted that D614G also
Molecular Epidemiology Analysis of SARS-CoV-2 Strains Circulating in Romania during the First Months of the Pandemic.
Result: These mutations, C3037T, C14408T (P323L in Nsp12) and A23403G (D614G in S), were present in all Romanian sequences.
Result: When looking into the GISAID database mutational statistics, which uses hCoV-19/Wuhan/WIV04/2019 EPI_ISL_402124 as a reference strain (COVsurver tool), both P323L and D614G mutations are present in a high percentage (61.7%/61.8%, n = 33480 and n = 33537).
Discussion: A subsequent study reported that A23403G (D614G in S) is becoming prevalent worldwide and associated with severe disease cases.
miRNA target prediction might explain the reduced transmission of SARS-CoV-2 in Jordan, Middle East.
Abstract: The exciting findings here that the nucleotide substitution 1841A > G at the viral genomic RNA level, which is an amino acid substation D614G at the spike protein level showed a change in the predicted miRNA sequence from hsa-miR-4793-5p to hsa-miR-3620-3p with an increase in the target score from 91 to 92.
Result: The interesting finding here that the 1841A > G, and D614G showed a change in the predicted miRNA and an increase in the target score from 91 to 92 (hsa-miR-4793-5p to hsa-miR-3620-3p).
A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants.
Abstract: We find limited diversity across SARS-CoV-2 genomes: Only 11 sites show polymorphisms in >5% of sequences; yet two mutations, including the D614G mutation in Spike, have already become consensus.
Abstract: While the rapid spread of the D614G mutation warrants further study, our results indicate that drift and bottleneck events can explain the minimal diversity found among SARS-CoV-2 sequences.
Discussion: A mutation, S612L, that emerged in MERS-CoV after passaging the virus in the presence of two antibodies (in 5/15 clones after 20 passages) warrants the evaluation of the analogous D614G mutation in SARS-CoV-2 for its ability to interfere with the recognition of a distal epitope.
Discussion: As such, on January 28, 2020, a virus carrying the D614G mutation,
SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution.
Result: Four genetically linked mutations previously described as the globally dominant haplotype in April 2020 were found in the majority of our consensus sequences: C241T (100%; 5'UTR region), C3037T (98.6%; silent mutation), C14408T (100%; resulting in P4715L/P323L amino acid change in ORF1ab) and A23403G (100%; resulting in D614G amino acid change in S).
Discussion: As expected, the P323L change in the RNA-dependent RNA polymerase (RdRp), genetically linked to D614G, was also found
Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene.
Result: 20A is a derivative of 19A and contains mutations C3037T, C14408T and A23403G (resulting in D614G).
Result: A total of 173 cases were analyzed to determine the number and relative proportion of the specimens which carried the Discussion: It is possible that these measures, compounded by potential inherent transmission variability of some viral isolates, influenced the change in the frequency of D614G, clades and P323L/F that we noted during this time period within Nevada.
Discussion: We find that the overall trend for D614G in Nevada during this time period was similar to what was observed in other states and internationally, with the exception of within Asia where the D614 allele had originated.
Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences.
Abstract: A virus mutation (D614G) may cause differing infectivity, while at the host level genetic, ethnicity-specific variants of the virus-binding entry proteins may facilitate virus entry in the olfactory epithelium and taste buds.
Mutation density changes in SARS-CoV-2 are related to the pandemic stage but to a lesser extent in the dominant strain with mutations in spike and RdRp.
Introduction: Claims of increased transmissibility of this new strain due to spike D614G mutation by were met with caution, as other factors such as founder effect, drift etc.
Introduction: However, animal studies will be required to further test the effects of the D614G mutation to reach a more definitive conclusion.
Introduction: Our previous study suggested that RdRp 14408 C>T mutation is associated with SARS-CoV-2 genome evolution and could even be working synergistically with the 23403 A>G (D614G) mutation.
Introduction: Soon after its spread to Europe and the US, a strain of SARS-CoV-2 with two non-synonymous mutations in the RNA-dependent RNA polymerase (
Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine Development.
PMID: 32884216
2020
Journal of laboratory physicians
Table: D614G
Figure: Two Major clades A and B are formed due to the most prevalent mutations D614G.
Discussion: Out of 88 SNP clusters, D614G was found in 34 (38.6%) SARS-CoV-2 genomes.
Discussion: The amino acid change in 23403A>G variant (p.D614G) involves a change of large acidic residue D (aspartic acid) into small hydrophobic residue G (glycine).
SARS_CoV_2 mutation literature information.
PMID: 
2020
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