Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
Abstract: Of the two viruses that were sequenced and were of the B.1 and B.4 lineages with one carrying the D614G mutation.
Abstract: Since the majority of those who were in this underserved settlement were not infected despite circulation of the D614G variant, it would be important to further study environmental and host factors that lead to disease severity and transmission.
Table: D614G
Discussion: Despite one of the viruses carrying the D614G mutation and despite this outbreak occurring in an extremely overcrowded area, it appears that only 89/2722 living in the 6,955 square meters (0.007 km2) area of the Bandaranayaka watta were infected.
Discussion: Of the two viruses, one carried the D614G mutation in the S protein, which have been associated with hig
Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption.
Discussion: It has been shown that the D614G substitution in the SARS-CoV-2 spike can promote virus entry into host cells and enhance infectivity as well as make the mutant virus resistant to neutralizing antibody.
Algorithm for the Quantitation of Variants of Concern for Rationally Designed Vaccines Based on the Isolation of SARS-CoV-2 Hawai'i Lineage B.1.243.
Abstract: RT-qPCR assays for the Original (D614G), Alpha and Beta variants had been previously developed and are being employed for wastewater surveillance.
Introduction: First evidence for such an evolutionary event for the SARS-CoV-2 virus occurred in April 2020, when the D614G substitution enhanced infectivity and transmission.
Introduction: The D614G mutation lineage became the dominant SARS-CoV-2 variant form.
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
PMID: 34755213
2021
Applied microbiology and biotechnology
Introduction: A SARS-CoV-2 pp assay (spike-pseudotyped particle) was conducted to examine the chances of immune escape due to the emergence of the D614G mutation, which insinuated the neutralizing effect of the antibodies against this mutation.
Introduction: A research report supported the chances that the D614G nucleotide substitution confers higher infectivity and transmissibility without better binding affinities to ACE2 receptors or over increased escape of immune surveillance mechanisms (Cheng et al.).
Introduction: Although the D614G mutation site is distant from the RBD, it still alters activity in the mutant variants.
Introduction: Another extremely virulent strain with the presence of D614G mutation is B.1.1.7, and it was first reported in the UK (Peters et
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil.
PMID: 34755818
2021
Memorias do Instituto Oswaldo Cruz
Introduction: A novel variant of the virus emerged at the end of January 2020 in lineage B.1 presented the spike protein substitution D614G.
Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021.
Result: Nonsynonymous mutations seen in the B.1.524 lineage sequences were nsp3-T1198I, nsp4-T28I, nsp5-T24A, nsp12-P323L, nsp13-L428F, spike-D614G, spike-A701V, and N-S194L.
Discussion: B.1.524 viruses carry the spike mutations D614G (present in most SARS-CoV-2 viruses) and A701V, which is also found in the VOC B.1.3
Epidemiology of COVID-19: An updated review.
PMID: 34759999
2021
Journal of research in medical sciences
Abstract: On the other hand, among 14 detected mutations in the SARS-CoV-2 S protein that provide advantages to virus for transmission and evasion form treatment, the D614G mutation (substitution of aspartic acid [D] with glycine [G] in codon 614 was particular which could provide the facilitation of the transmission of the virus and virulence.
Abstract: Of 359 mutations detected, 60.5% of which were non-synonymous, the most frequent were in the ORF1ab (P4715L), S (D614G and A701V) and N (S194L) genes.
Resul
Result: As shown in Table 1 above, the D614G amino acid substitution in the S spike protein was observed in 159 of 277 (57.4%) genomes.
Result: Based on the isolation dates in GISAID, this mutation was present in the viruses isolated in March 2020, suggesting that D614G was present in Malaysia before it was first reported in the Sivaganga cluster in July-August 2020.
Table: D614G
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
SARS_CoV_2 mutation literature information.
PMID: 
2021
PloS one
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