Discussion: This mutation along with D614G had been found to decrease the sensitivity of convalescent sera and thus more likely to evade immune responses.
Discussion: This mutation in combination with D614G had demonstrated increased infectivity and enhanced transmissibility.
Insights on the SARS-CoV-2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics.
Abstract: From 720 SARS-CoV-2 genome sequences, we found few sites under positive selection pressure, such as the D614G (98.5 %) in the spike, that has replaced the old variant; the V1167F in the spike (41 %), identified in the P.2 variant that emerged from Brazil during the period of analysis; and I292T (39 %) in the N protein.
Introduction: Among them, the variants P.1 and P.2, first isolated in Brazil possess substitutions of interest in the S protein, including K417T, E484K, N501Y, D614G, and H655Y.
Result: From those, only the substitutions
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants.
PMID: 34732694
2021
Signal transduction and targeted therapy
Result: During the circulation of SARS-CoV-2, the notable mutation D614G became the first dominant variant and replaced the ancestral spike.
Result: In align with this, the binding affinity of n3113.1-Fc with D614G spike showed no difference with the wild-type spike (WT S) (5.5 nM for WT S and 5.3 nM for D614G S.
Result: N3113.1-Fc neutralized pseudoviruses loaded with a spike of WT-D614G and Alpha variant in indiscriminate potent (IC50 of 0.07 mug/ml and 0.12 mug/ml for WT-D614G and Alpha, respectively.
Result: We generated a D614G mutation into the prefusion-stabilized spike for cryo-EM structure determination.
Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and Transmission.
Abstract: D614G, Q57H, and S194L mutations were correlated with mild and severe outcome with high prevalence.
Introduction: The D614G variant in the S glycoprotein was associated with increased transmissibility, infectivity, and viral loads but not with disease severity.
Result: D614G increased from 74.6% to 99.9%; T265I, Q57H, R203K, and G204R started to increase in March and gradually decreased in July (Figure 3D).
Table: D614G
Discussion: D614G and S194L were found to be associated with severe outcomes with hi
Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.
PMID: 34735950
2021
Computers in biology and medicine
Discussion: D614G is considered to be more infectious than the ancestral form but not associated with increased disease severity.
Discussion: For example, D614G is often considered together with P323L.
Discussion: Some researchers suggest the inability of D614G to cause viral success when presented alone.
Discussion: The most frequent mutation in the analyzed genes was a mutation in the S gene - A23403G (D614G), which was found in 94.15% of all studied genomes and in 99.9% of genomes uploaded in December 2020.
Discussion: The only interesting message was an article stating that this mutation co-mutates with infectivity-enhancing S protein mutations, such as
Discussion: After March 2020, the D614G clade became increasingly prevalent worldwide, expanding from 22 to 42 countries with GH (D614G + Q57H in the NS3) dominant in North America (59.0%).
Discussion: Our data from March showed that most of the SARS-CoV-2 had mutation particularly in D614G that may be D614G variant previously described.
Discussion: Our study found B.1.1.7 variant with mutation mainly in D614G, N501Y and del 69-70 was prevalent in all five months predominantly in April and May.
Discussion: The
Discussion: The emergence of new variants was led by the global rise of the D614G mutation in the Wuhan strain identified in China and Germany.
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern.
Abstract: In humans, vaccinated phase 1 subjects still showed appreciable neutralization abilities against the D614G, Alpha, and Beta variants, although neutralizing titers were significantly reduced against the Beta variant.
Abstract: The neutralizing titers of serum antibodies were assayed with pseudoviruses coated with the SARS-CoV-2 spike protein of the wild-type (WT), D614G, Alpha, or Beta variants.
Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern.
Discussion: At low target cell ACE2 levels, the relative ability of the different SARS-CoV-2 S glycoproteins to mediate virus entry exhibited the following rank order: P.1, B.1.1.248 > B.1.351 > B.1.1.7 > D614G > D614.
Discussion: However, we note that, as previously seen, the D614G S is more stable and sheds S1 less at 0 or 4 C than the D614 S, yet these two variants exhibit minimal differences in the rate of decay of infectivity at these temperatures.
Discussion: In this study, we compared the functional properties of the S glycoproteins of emerging SARS-CoV-2 variants with those of the original/founder D614 strain and the globally dominant D614G variant.
Discussion: Incubation on ice or at 4 C led to rapid loss of infectivity
Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
Abstract: Of the two viruses that were sequenced and were of the B.1 and B.4 lineages with one carrying the D614G mutation.
Abstract: Since the majority of those who were in this underserved settlement were not infected despite circulation of the D614G variant, it would be important to further study environmental and host factors that lead to disease severity and transmission.
Result: One of the viruses had the D614G mutation.
Table: D614G
Discussion: Despite one of the viruses carrying the D614G mutation and despite this outbreak occurring in an extremely overcrowded area, it appears that only 89/2722 living in the 6,955 square meters (0.007 km2) area of the Bandaranayaka watta were infected.
Discussion: Of the two viruses, one carried the D614G m
Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption.
Discussion: It has been shown that the D614G substitution in the SARS-CoV-2 spike can promote virus entry into host cells and enhance infectivity as well as make the mutant virus resistant to neutralizing antibody.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of medical virology
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