A Multidimensional Cross-Sectional Analysis of Coronavirus Disease 2019 Seroprevalence Among a Police Officer Cohort: The PoliCOV-19 Study.
PMID: 34888394
2021
Open forum infectious diseases
3Introduction: We also measured antibody titers of naturally acquired SARS-CoV-2 infection and correlated the results with the neutralizing capacity of the antibodies towards the ""wild-t
Abstract: Serum neutralization titers toward the wild-type SARS-CoV-2 spike protein (expressing D614G) and the Alpha and Beta variants were measured in seropositive study participants.
Discussion: Considering that the sampling occurred from 9 February to 9 March, the vast majority of our cohort was exposed to the virus strain harboring the D614G S protein.
Discussion: In line with these observations, naturally acquired antibodies demonstrated good neutralization activity against D614G but performed suboptimally against the Alpha variant and poorly against the Beta variant.
Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia.
Discussion: Indeed, mRNA based (Moderna, Pfizer-BioNTech), adenoviral based (Vaxzevria, Johnson&Johnson), and protein-based based (Novavax) vaccines are only able to induce a monoclonal response towards the Asp614Gly bearing SARS-CoV-2 Spike protein, therefore a steady acquisition of mutations that could eventually lead to an enhanced fitness should be carefully monitored.
Estimating the strength of selection for new SARS-CoV-2 variants.
Discussion: A different type of phylogenetic analysis found no support for a selective advantage of any of the variants they tested, including D614G, presumably because their statistical test required the repeated emergence of a variant in order to draw any power.
Discussion: Our analyses point to strong selection favoring D614G and B.1.1.7, some selection favoring B.1.351, and not a global advantage for R.1.
Discussion: Several studies using other methods have similarly found D614G and B.1.1.7 to each have a selective advantage over other variants circulating contemporaneously.
Discussion: That is, the fitness of B.1.1.7 exceeds that of D614G, which itself exceeds the original genotype.
Discussion: Third, the UK has put effort into developing a representative sample of
Comparative MD Study of Inhibitory Activity of Opaganib and Adamantane-Isothiourea Derivatives toward COVID-19 Main Protease M(pro).
Conclusion: Also, molecular docking simulations are performed to predict the potential inhibitory potency of compounds 1-4 toward SARS-CoV-2 main protease Mpro and mutation of SARS-CoV-2 Spike (S) Protein D614G.
Conclusion: As regard molecular docking simulations with Spike (S) Protein D614G, the prominent inhibitory potency shows OPG, while examined adamantly- isothiourea derivatives possess similar inhibitory potential between each other.
Conclusion: The important thermodynamical parameters from docking simulations with D614G, Table S
Figure: Structure of Spike (S) protein (D614G) and its interactions with OPG and compounds 1-4.
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant.
Result: Additionally, mutations such as D614G have previously been linked to increased infectivity via destabilization of the RBD-down spike protein conformation.
Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection.
Result: At the time of pre-vaccination sample collection D614G was the major circulating SARS-CoV-2 variant, while at the time off post-first dose and post-second dose D614G and Alpha were circulating, and at the six month time point Delta was the dominant strain.
Result: Following the first dose of mRNA vaccine, a strong nAb response was induced among HCWs compared to pre-vaccination across all variants (p < 0.001), which efficiently blocked virus entry; this was despite the huge variation in nAb titers of these individuals including against D614G (mean = 1140, 95% CI = 317-1963, range = 100-15954).
Result: In particular, following two vaccine doses, mRNA-1273 vaccinated HCWs exhibited 2.1-, 2.3-, 2.4-, and 1.3-fold higher nAb response compared to BNT162b2-vaccinated HCWs for D614G, Alpha, Beta, and Delta variants, respectively.
Clinical and genomic signatures of rising SARS-CoV-2 Delta breakthrough infections in New York.
Discussion: Although Delta shows compromised sensitivity to some RBD and NTD neutralizing antibodies with up to 8-fold reduced sensitivity in vitro to vaccine-induced antibodies compared to D614G viruses (including infectious virus assays), neutralization escape is substantially lower in magnitude as compared to Beta, Gamma, and Mu.
SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.
Method: P2 stock was sequenced and confirmed Omicron with the following substitutions: E:T9I,M:D3G,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,ORF1a:K856R,ORF1a:L2084I,ORF1a:A2710T,ORF1a:T3255I,ORF1a:P3395H, PMID: 34910734
2021
PloS one
Abstract: The highest mutations observed in mink where the substitution of D614G in spike (95.2%) and P323L in NSP12 (95.2%) protein.
Result: The D614G in spike protein and P323L in non-structural protein 12 (NSP12) were the most prevalent (95.2%) mutations in minks.
Discussion: D614G mutation is a very common variant in human populations worldwide.
Discussion: Another commonest mutation was D614G in mink found in almost 95% of minks.
Introduction: In December 2020, the variant B.1.351 was first detected in South Africa, with mutations such as K417N, E484K, N501Y, D614G, and A701V.
Introduction: In this regard, the variant B.1.1.7 was first identified in the United Kingdom, which contains E484K, N501Y, D614G, and P681H mutations in Spike glycoprotein.
Introduction: On the other hand, the variant B.1.617.2 was first identified in India with L452R, T478K, D614G, and P681R mutations in Spike glycopr
SARS_CoV_2 mutation literature information.
PMID: 
2021
Open forum infectious diseases
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