Abstract: RT-qPCR assays for the Original (D614G), Alpha and Beta variants had been previously developed and are being employed for wastewater surveillance.
Introduction: First evidence for such an evolutionary event for the SARS-CoV-2 virus occurred in April 2020, when the D614G substitution enhanced infectivity and transmission.
Introduction: The D614G mutation lineage became the dominant SARS-CoV-2 variant form.
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
PMID: 34755213
2021
Applied microbiology and biotechnology
Introduction: A SARS-CoV-2 pp assay (spike-pseudotyped particle) was conducted to examine the chances of immune escape due to the emergence of the D614G mutation, which insinuated the neutralizing effect of the antibodies against this mutation.
Introduction: A research report supported the chances that the D614G nucleotide substitution confers higher infectivity and transmissibility without better binding affinities to ACE2 receptors or over increased escape of immune surveillance mechanisms (Cheng et al.).
Introduction: Although the D614G mutation site is distant from the RBD, it still alters activity in the mutant variants.
Introduction: Another extremely virulent strain with the presence of D614G mutation is B.1.1.7, and it was first reported in the UK (Peters et
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil.
PMID: 34755818
2021
Memorias do Instituto Oswaldo Cruz
Introduction: A novel variant of the virus emerged at the end of January 2020 in lineage B.1 presented the spike protein substitution D614G.
Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021.
Abstract: It is due to lineage B.1.524 viruses containing spike mutations D614G and A701V.
Result: Nonsynonymous mutations seen in the B.1.524 lineage sequences were nsp3-T1198I, nsp4-T28I, nsp5-T24A, nsp12-P323L, nsp13-L428F, spike-D614G, spike-A701V, and N-S194L.
Discussion: B.1.524 viruses carry the
Epidemiology of COVID-19: An updated review.
PMID: 34759999
2021
Journal of research in medical sciences
Abstract: On the other hand, among 14 detected mutations in the SARS-CoV-2 S protein that provide advantages to virus for transmission and evasion form treatment, the D614G mutation (substitution of aspartic acid [D] with glycine [G] in codon 614 was particular which could provide the facilitation of the transmission of the virus and virulence.
Abstract: Of 359 mutations detected, 60.5% of which were non-synonymous, the most frequent were in the ORF1ab (P4715L), Introduction: Other prominent outbreaks included the Pesantren cluster in April that was linked to Malaysian students returning from a religious school in East Java, Indonesia, and the Sivaganga cluster in July-August that was traced to a Malaysian who returned from India carrying the D614G variant.
Table: D614G
Discussion: Among the mutation hotspots only D614G and A701V in the spike protein as well as P4715L and T2015I in ORF1ab are known to have a world-wide prevalence.
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation.
PMID: 34763050
2021
Infection, genetics and evolution
Discussion: In SARS-CoV-2 some mutations were correlated with advantages, as the increase of rate of transmission (example: D614G mutation and Gamma variant) and decrease neutralizing antibodies.
Discussion: Prior to March, the D614G was present in 10% of global sequences, from 1st to March 31, 2020, the detection rate already reached 67% of sequences and, from 1st April to May 18, 2020, the D614G mutations have already been observed in 78% of the sequences .
Discussion: The D614G for D614A change has already been identified in July 2020 in three individuals who returning to Korea from Uzbekistan .
Discussion: The D614G is a relevant Spike mutation observed in early March 2020 .
Discussion: This rapid spread and dominancy
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Abstract: A new B.1.524(G) lineage with S-D614G mutation was detected in Sabah, East Malaysia and Selangor, Peninsular Malaysia on 7th October 2020 and 14th October 2020, respectively.
Result: So far, only strains that fell within this B.1-associated lineage carried this S-D614G amino acid substitution.
Result: The A23403G was encoded for substitution of aspartic acid with glycine in the S-614 (S-D614G).
SARS_CoV_2 mutation literature information.
PMID: 
2021
bioRxiv
Browser Board
Co-occurred Entities
Filtrator
ViMRT