Abstract: Of 359 mutations detected, 60.5% of which were non-synonymous, the most frequent were in the ORF1ab (P4715L), Introduction: Other prominent outbreaks included the Pesantren cluster in April that was linked to Malaysian students returning from a religious school in East Java, Indonesia, and the Sivaganga cluster in July-August that was traced to a Malaysian who returned from India carrying the D614G variant.
Table: D614G
Discussion: Among the mutation hotspots only D614G and A701V in the spike protein as well as P4715L and T2015I in ORF1ab are known to have a world-wide prevalence.
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation.
PMID: 34763050
2021
Infection, genetics and evolution
Discussion: In SARS-CoV-2 some mutations were correlated with advantages, as the increase of rate of transmission (example: D614G mutation and Gamma variant) and decrease neutralizing antibodies.
Discussion: Prior to March, the D614G was present in 10% of global sequences, from 1st to March 31, 2020, the detection rate already reached 67% of sequences and, from 1st April to May 18, 2020, the D614G mutations have already been observed in 78% of the sequences .
Discussion: The D614G for D614A change has already been identified in July 2020 in three individuals who returning to Korea from Uzbekistan .
Discussion: The D614G is a relevant Spike mutation observed in early March 2020 .
Discussion: This rapid spread and dominancy
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Abstract: A new B.1.524(G) lineage with S-D614G mutation was detected in Sabah, East Malaysia and Selangor, Peninsular Malaysia on 7th October 2020 and 14th October 2020, respectively.
Result: So far, only strains that fell within this B.1-associated lineage carried this S-D614G amino acid substitution.
Result: The A23403G was encoded for substitution of aspartic acid with glycine in the S-614 (S-D614G).
Table: D614G
An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms.
Result: A query of all GISAID sequences from Neovison vison viruses revealed that 95.4% had mutations D614G and N501T.
Result: One of the two mink from farm A had mutations at T85I-NSP2, S1205L-NSP3, G37E-NSP9, P323L-NSP12, T91M-NSP15, D614G-spike, N501T-spike, Q57H-NS3, H182Y-NS3, and T205I-N
Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells.
Introduction: Using the WHO nomenclature, examples of such mutations in the spike include the mutation at residue 614, alpha/b
Result: 5) and for the alpha/beta/gamma mutant [D614G] S1 protein.
Result: Figure 1c, d show the same descriptive positive cooperativity behavior in Eadie-Hofstee plots for both the alpha/beta/gamma [D614G] S1 protein and the Original [D614] RBD protein, respectively.
Result: However, the binding isotherm for the mutant alpha/beta/gamma [D614G] S1 differs quantitatively from that of the Original S1 and Original RBD.
Result: We also found similar results for inhibition of ACE2 binding to the alpha,beta,gamma mutant [D614G] S1 (Supplemental.
Table: D614G
Sequencing of SARS-CoV-2 in local transmission cases through Oxford Nanopore MinION platform from Karachi Pakistan.
PMID: 34780358
2021
Journal of infection in developing countries
Abstract: All the isolates belonged to GH clade and shared missense mutation D614G in spike protein linked to increased transmission rate worldwide.
Abstract: Another spike protein mutation A222V coexisted with D614G in the virus from the second wave of COVID-19.
Infection, recovery and re-infection of farmed mink with SARS-CoV-2.
Result: These methods were used to detect the D614G mutation, which arose in the first months of the pandemic and has become dominant worldwide as a consequence of providing higher infectivity to the virus.
CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern.
Abstract: Our results indicated that the CRISPR-Cas12a assay could readily detect the signature spike protein mutations (K417N/T, L452R/Q, T478K, E484K/Q, N501Y, and D614G) to distinguish alpha, beta, gamma, delta, kappa, lambda, and epsilon variants of SARS-CoV-2.
Introduction: It has been reported that D614G substitution in the S protein can affect viral infectivity and antigenicity.
Method: The SARS-CoV-2 target sequences include (i) the wild
Result: Finally, crRNA-S-614D was used to distinguish the D614G mutation.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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