Introduction: Another mutation in the S-glycoprotein region is D614G, which is associated with immune escape.
Introduction: Few mutations include K417T/N, E484K, L452R, N501Y, P681R, D614G, etc.
Introduction: In this direction, we illustrated the mutations in the RBD region (N439K, L452R, E484K,
Introduction: first reported this novel mutation of D614G, and they concluded that this mutation might be responsible for altered antigenicity and immunogenicity.
Table: D614G
Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2.
Method: For instance, a Delta variant spike haplotype consisting of T19R, 256_258delinsG,
Result: At 1 week after vaccination, strong neutralization (hiVNT score > 70) of all variants was observed in most of the sera samples, ranging from the highest (95.2%) in D614G to the lowest in the Beta variant (70.6 %) (Figure 3).
Result: The geometric mean titers (GMTs) were 225 for D614G, 38 for Beta, and 37 for Delta + E484K + N501Y (Figure 2A), suggesting that the sera had 6-fold reduced neutralization efficacy against the Beta and Delta variants.
Figure: Since these nAbs are treated as a cocktail, they are considered effective if the EC50 of either antibody is equivalent to or lower than that of the D614G control.
Variants of SARS CoV-2: mutations, transmissibility, virulence, drug resistance, and antibody/vaccine sensitivity.
PMID: 35227008
2022
Frontiers in bioscience (Landmark edition)
Abstract: Mutations in the S protein that are common among several of the variants include D614G that increases transmissibility and viral load and is often associated with P323L on the RNA dependent RNA polymerase.
In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Abstract: The most frequent non-synonymous mutation 486/546 (89.01%) occurred in the S gene (structural gene) at position 23,403 where A changed to G leading to the replacement of aspartic acid by glycine in position (D614G).
Result: The most frequent non-synonymous mutation 486/546 (89.01%) occurred in the S gene at position 23,403 where A changed to G leading to the replacement of aspartic acid by glycine in position (D614G)) Table 3 and.
Table: D614G
Discussion: A23403G (D614G) was observed in West European states in the early stage of the disease and this finding might point towards the source of infection from which it was introduced in India.
Discussion: Moreover, the present study showed that
SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity.
Discussion: Here, we showed preservation of Fc effector function against VOCs both in individuals previously infected with the original D614G variant and in individuals vaccinated with Ad26.COV2.S.
Discussion: This is supported by a recent study measuring natural killer (NK) activation, ADCP, ADCD, and ADCC in Ad26.COV2.S vaccinees showing differences of under 2-fold between original D614G and Beta.
Discussion: This was despite the fact that the sequence of immunodominant regions of the eliciting immunogens were the same, with only the single D614G mutation differing between them.
Discussion: We also show subtle differences in the ability of antibodies elicited by either the original D614G or the Ad26.COV2.S vaccine to perform ADCC a
Rapidly Identifying New Coronavirus Mutations of Potential Concern in the Omicron Variant Using an Unsupervised Learning Strategy.
Abstract: To build an investigative framework, we have applied an unsupervised machine learning approach to 4296 Omicron viral genomes collected and deposited to GISAID as of December 14, 2021, and have identified a core haplotype of 28 polymutants (A67V, T95I, G339D, R346K, S371L, S373P, S375F, K417N,
Introduction: Note that we use a polymutant nomenclature without the ending amino acid designated, e.g., D614 as opposed to D614G, because several polymutants exhibit multiple mutations.
Introduction: Some, like D614G, are observed in all three variant families and the impact of this mutation has been well documented.
"VE607 Stabilizes SARS-CoV-2 Spike In the ""RBD-up"" Conformation and Inhibits Viral Entry."
Abstract: The IC 50 values are in the low micromolar range for pseudoparticles derived from SARS-CoV-2 Wuhan/D614G as well as from variants of concern (Alpha, Beta, Gamma, Delta and Omicron), suggesting that VE607 has potential for the development of drugs against SARS-CoV-2 infections.
Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion.
Introduction: For example, the D614G mutation, identified during the earlier stage of the pandemic, promotes spike binding to ACE2, leading to enhanced virus transmission.
Result: To further examine the biological impact of these mutations on cell entry, we produced pseudotyped virus particles containing a firefly luciferase reporter gene and expressing on their surface with the spike proteins of WT (D614G), Kappa, Delta, and B.1.618 variants.
Result: To this end, we used an SARS-CoV-2 tran
Figure: Luciferase activity was determined after 2 days of infection, and data were normalized to the WT (D614G) of the individual experiment.
Figure: This experiment was repeated twice independently, and data were normalized to the WT (D614G) of the individual experiment.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Diagnostic microbiology and infectious disease
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