Abstract: All four variants of concern carry the D614G mutation, which indirectly enhances S1/S2 cleavability by furin.
Introduction: All of these VOCs have the D614G mutation (Figure 5).
Introduction: As mentioned earlier, SARS-CoV-2 with the D614G mutation, which emerged early in the epidemic and has become a major cause of the global pandemic, has gained increased infectivity because of the D614G mutation.
Introduction: Besides, the 614th amino acid is located in the vicinity of the S1/S2 cleavage site (Figure 7), and the D614G mutation increases S1/S2 cleavability by furin (Figure 5).
Introduction: In fact, the D614G mutation is of great significance when the S protein contains an FCM.
Introduction: Neverthele
BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in systemic lupus erythematosus.
PMID: 34607791
2022
Annals of the rheumatic diseases
Figure: (A) Comparison of serum anti-RBD IgG levels measured by photonic ring immunoassay with neutralising capacity against D614G SARS-CoV-2 (n=126).
Figure: (B) Serum neutralising activities against D614G SARS-CoV-2 measured as inhibitory dilution 50 (ID50) in 126 serum samples at D42.
Figure: (C) Comparison of serum neutralising activities measured as ID50 against D614G SARS-CoV-2 in patients with systemic lupus erythematosus (SLE) with baseline low (grey, n=19) or high (black, n=40) naive B cell frequency (arbitrary cut-off=42% of total B cells).
Figure: (D) Serum neutralising activities against D614G SARS-CoV-2 measured as ID50 in 59 patients with PMID: 34624095
2022
The Journal of infectious diseases
Abstract: The world's first coronavirus disease 2019 human challenge trial using the D614G strain of severe acute respiratory syndrome 2 (SARS-CoV-2) is underway in the United Kingdom.
High throughput sequencing based direct detection of SARS-CoV-2 fragments in wastewater of Pune, West India.
PMID: 34688738
2022
The Science of the total environment
Result: Notably, nine mutations in the Spike region (S: L452R, S:C480R, S: E484Q, S: D614G, S: P681R, S: N801, S: D950N, S: Q1071H, S: P1140) were observed in this study (Table 1, Supplementary Table 2).
Table: D614G
Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Hyperimmune Immunoglobulin Demonstrates Potent Neutralization and Antibody-Dependent Cellular Cytotoxicity and Phagocytosis Through N and S Proteins.
PMID: 34693968
2022
The Journal of infectious diseases
Abstract: METHODS: Functional characterization of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hyperimmune immunoglobulin (hIG) from human convalescent plasma was performed by different virus neutralization methodologies (plaque reduction, virus-induced cytotoxicity, median tissue culture infectious dose [TCID50] reduction, and immunofluorimetry) at different laboratories using geographically different SARS-CoV-2 isolates (USA [1], Italy [1], and Spain [2]; 2 containing the D614G mutation).
Abstract: Neutralization capacity against the original Wuhan SARS-CoV-2 strain and variants (D614G mutant, B.1.1.7, P.1, and B.1.351) was evaluated using a pseudovirus expressing the corresponding spike (S) protein.
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.
PMID: 34726473
2022
Science translational medicine
Abstract: Here, we demonstrate the neutralization of SARS-CoV; bat coronaviruses WIV-1 and RsSHC014; and SARS-CoV-2 variants D614G, B.1.1.7, B.1.351, P.1, B.1.429, B.1.526, B.1.617.1, and B.1.617.2 by a receptor binding domain (RBD)-specific human antibody, DH1047.
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
Result: Among other O-glycosylation sites, we only detected a low level of O-glycosylation at T678 located within the loop that harbors the furin cleavage site for the GSAS-stabilized S-fm2P but not S-D614G or S-Alpha (Supplementary Table SIV).
Result: In our hands, N343 does have a few oligomannose structures (~15%) but, importantly, both sites carry mostly complex type structures and are not appreciably affected by mutations in the D614G and Alpha variants.
Result: Interestingly, although single mutation at D614G retains much of the same glycosylation pattern, a significant shift is noted in the Alpha variant more than in any other sites.
Result: Like the Harvard and Swiss samples, our own S-fm2P sample yielded a small % of complex
Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.
Discussion: Certain studies reported the increment in viral load in the upper respiratory tract (URT) of patients infected with the D614G mutant type virus.
Discussion: Several studies have implied that the D614G mutation in the spike glycoprotein of SARS-CoV-2, being closely located in the receptor-binding domain.
Discussion: The spike protein of SARS-CoV-2 is more prone to multiple point mutations, most notable being D614G (Asp614-to-Gly) variant (globally dominant viral form) with increment in transmissibility, infectivity and neutralization susceptibility.
Analysis of SARS-COV2 spike protein variants among Iraqi isolates.
Abstract: The most frequently mutations occurred at the D614G (87/91), followed by S982A (50/91), and A570D (48/91), respectively.
Abstract: Twenty-two distinct mutations were identified within the spike protein regions which were: L5F, L18F, T19R, S151T, G181A, A222V, A348S, L452 (Q or M),
Introduction: A variant that carries D614G mutation in the spike protein of the virus, also known as G clade or B.1, was diagnosed during the early days of the pandemic in the north of America, and then reported in many European countries.
Reduced levels of convalescent neutralizing antibodies against SARS-CoV-2 B.1+L249S+E484K lineage.
Introduction: In February 2020, in the early stages of the pandemic, the B.1 lineage emerged in Europe with the characteristic D614G mutation in the S protein, which distinguishes it from the A and B ancestral lineages.
Result: Regarding B.1.111 isolates, although both share the mutation pattern characteristic of the B.1.111 lineage (Spike D614G, NS3 Q57H and NSP12 P323L), several divergent genome wide mutations were observed between those isolates, for example, EPI_ISL_794659 have two additional mutations at the S protein (Spike T859I
SARS_CoV_2 mutation literature information.
PMID: 
2022
Microbiology and immunology
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