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 SARS_CoV_2 mutation literature information.


  SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.
 PMID: 35273977       2022       Frontiers in medicine
Introduction: D614G in the RBM domain has shown to increase the S-protein density on the viral surface, thereby enhancing infectivity.
Introduction: And cilgavimab had lower activity against N501Y+D614G mutants, including B.1.429 (carrying L452R), B.1.617.2 (carrying L452R + T478K) and B.1.351 (carrying K417N + E484K + N501Y).
Introduction: Both P4715L and P323L was observed along with S protein D614G mutation, suggesting a co-evolutionary pattern.


  Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivity.
 PMID: 35293847       2022       Emerging microbes & infections
Figure: Data show the neutralization ID50 ratio of each variant, compared with the D614G reference strain.
Figure: Fluorescence signals of GFP were normalized to the signal of the D614G reference strain after 1 h of co-incubation; values shown indicate means +- SEMs.
Figure: Neutralization activities of from animals immunized with D614G and other SARS-CoV-2 variants.


  Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.
 PMID: 35290827       2022       EBioMedicine
Introduction: The spike protein of Delta contains 9 mutations, when co
Method: The D614G spike plasmid was generated by introducing the mutation into the Wuhan reference strain via Q5 site-directed mutagenesis (NEB).
Result: As previously reported, the D614G and Alpha spike variants were less fusogenic than the Delta spike (Figure 2a, b, Figure S2).


  Design of SARS-CoV-2 Variant-Specific PCR Assays Considering Regional and Temporal Characteristics.
 PMID: 35285246       2022       Applied and environmental microbiology
Result: As a result, for the Alpha variant, we identified nine mutations in the spike gene: S:Delta69/70, S:Delta144, S:N510Y, S:A570D, S:D614G, S:P681H, S:T716I, S:S982A, and S:D1118H.
Result: For the Delta variant, we identified seven mutations: S:T19R, S:Delta156/157, S<


  SARS-CoV-2 infection after vaccination in Italian health care workers: a case report.
 PMID: 35283546       2022       National Academy science letters. National Academy of Sciences, India
Abstract: Their genotyping performed on RNA extracts highlighted the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) sequence variants, all indicative of VOC 202012/01-lineage B.1.1.7, suggesting a common source of infection.
Result: The genotyping performed first by Real-time PCR and then confirmed by direct sequencing proved the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) variants, indicative of VOC 202,012/01-lineage B.
Figure: Sections from the electropherograms showing the 69/70, N501Y, A570D, and D614G (a., b., c., d.) associated with SARS-CoV-2 Alfa Variant B.1.1.7.


  Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections.
 PMID: 35281007       2022       Frontiers in immunology
Discussion: Further follow-up will be needed to confirm whether the specific Nab titer against D614G is maintained or not.
Discussion: The neutralizing titer against D614G significantly decreased in sera of 6-8 months post onset compared to those of 1-3 months post onset ( Figure 3B ).
Discussion: The purpose of this study was to examine the longevity of Nab activity of COVID-19 convalescent sera against D614G, and their neutralizing breadth against B.1.1.7, P.1, and B.1.351.

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