literature

SARS_CoV_2 mutation literature information.

Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.

PMID: 32451533 2020 American journal of clinical pathology

Table: D614G

Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?

PMID: 32464271 2020 International journal of infectious diseases

Introduction: For example, a substantial number of strains with the S-D614G variant are from the countries Belgium, Spain, Italy, France, Netherlands, and Switzerland that top the death toll (Figure 1B) (https://www.worldometers.info/coronavirus/; last accessed May 2, 2020); while Germany and Kuwait, with a lower death toll, constitute most strains with the wild-type 614D at S (Figure 1B).

Introduction: Overall, our observation speculates that the S-D614G strains may be more

Figure: The mutation observed at the S protein of the SARS-COV-2, D614G in white color, may create conformational changes mimicking the open status and facilitate the cleavage domain's exposure to proteases FURIN or TMPRSS2 and could be sufficient to speed up the cleavage.

Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type.

PMID: 32474553 2020 The Indian journal of medical research

Abstract: INTERPRETATION & CONCLUSIONS: SARS-CoV-2 belonging to the A2a type possesses a non-synomymous variant (D614G) that possibly eases the entry of the virus into the lung cells of the host.

Introduction: Although the effect of the D614G mutation is unclear, this mutation is located in the S1-S2 junction near the furin recognition site (R667) for the cleavage of S protein that is required for the entry of the virion into the host cell.

Introduction: Another mutation, A23403G, located in the gene encoding the spike glycoprotein results in an amino acid change (

The origin of SARS-CoV-2 in Istanbul: Sequencing findings from the epicenter of the pandemic in Turkey.

PMID: 32478289 2020 Northern clinics of Istanbul

Result: Since all three isolates have a D614G variant in spike glycoprotein

Discussion: All three viral isolates carried the D614G marker variant indicating the isolates belong to clade G, which encompasses mostly European countries according to GISAID classification.

Discussion: Clades were named based on variants L84S in ORF8 (S clade), D614G in S gene (G clade), and G251V in ORF3a (V clade).

An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations.

PMID: 32511374 2020 bioRxiv

Method: Two mutants associated with European Covid-19 patients were constructed using CHARMM-GUI: one is the main strain mutant D614G and the other contains four mutations including Q239K, A831V, D614G and D839Y.

Result: Interestingly, the SARS-CoV-2 spike binding region harbors three residues that have been recently reported to have mutated in new strains from Europe and USA: D614G, A831V and D839Y/N/E).

Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.

PMID: 32515358 2020 Journal of biosciences

Abstract: More importantly, the possible implications of mutation D614G (in SD domain) and G1124V (in S2 subunit) on the structural stability of S protein have also been discussed.

Abstract: Specific mutations, characteristic of the A2a clade, were also detected, which included the P323L in RNA-dependent RNA polymerase and D614G in the Spike glycoprotein.

Discussion: Interestingly, the mutations D614G (in SD domain) is supposed to confer flexibility in the SD domain and the mutation G1124V might impart partial rigidity in the conformation of S2 domain.

SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East.

PMID: 32543353 2020 Emerging microbes & infections

Result: In addition to the signature mutation S-D614G annotated by GISAID in clade III, all the Taiwanese genomes shared two ORF1ab mutations C2772T and C14144T (P4715L) (Figure 3E).

Result: To better illustrate phylogenetic clades, we designated and numbered yellow clade as IV harbouring ORF1ab-V378I mutation in this study and three others (blue clade I of ORF8-L84S, gray clade II of ORF3a-G251V, and pink clade III of S-D614G) identified based on previous GISAID annotations of clades S,

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 32577641 2020 bioRxiv

Abstract: Several Spike-protein mutations, including D614G, which has been associated with increased transmission, disrupt otherwise-perfectly-conserved amino acids, and could be novel adaptations to human hosts.

Result: First, we investigated Sarbecovirus conservation of 14 amino acids in the spike protein in which mutations appear to be accumulating in the SARS-CoV-2 population, namely D614G, L5F, L8V/W, H49Y, Y145H, Q239K, V367F, G476S, V483A, V615I/F, A831V,

PMID: 32587973 2020 bioRxiv

Abstract: SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission.

Introduction: Instead, these data show there is more S1 domain in the SG614-expressing cells, a result again consistent with the observation that the D614G mutation reduces S1 shedding.

Introduction: It has also been speculated that the D614G mutation woul

An updated analysis of variations in SARS-CoV-2 genome.

PMID: 32595352 2020 Turkish journal of biology

Result: A23403G variation is one of the most important variations that have been reported previously (Phan et al., 2020) caused D614G substitution on S protein.

Table: D614G

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