Conclusion: The highly prevalent 23403A>G (p.D614G) variant in the European population ma
Discussion: A recent report corroborated our findings of high prevalence of D614G in Europe.
Discussion: However, given the small sample size, it is hard to ascertain whether D614G is the dominant strain in these countries.
Discussion: In addition to the Netherlands, Switzerland, and France, our data indicate that the D614G sub-strain is frequently detected in Brazil, Finland, and Belgium.
Discussion: Intriguingly, in our data the D614G variant was detected only in 2 out of 151 Chinese patients analyzed.
Discussion: Notably, these two samples do not share common variants besides p.D614G.
A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?
Abstract: These two subtypes were divided by a novel synonymous mutation of D614G.
Introduction: If the mutation of D614G plays a crucial role in the positive selection process, SARS-CoV-2b will be the dominant type of SARS-CoV-2 in the future.
Introduction: Since no amino acid changes were found in this area other than the change of D614G, it is believed that this amino acid change alters the conformation of these immunogenic determinants; consequently, this region is expected to no longer act as a B-cell epitope in SARS-CoV-2b.
Introduction: The results of the antigenic index analysis showed severely reduced indexes of amino acids 615-617 in the SARS-CoV-2b strains compared to SARS-CoV-2a; it is predicted that the change of D614G affects the antigenicity of this region (Figure 1F).
Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.
PMID: 32451533
2020
American journal of clinical pathology
Table: D614G
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
PMID: 32464271
2020
International journal of infectious diseases
Introduction: For example, a substantial number of strains with the S-D614G variant are from the countries Belgium, Spain, Italy, France, Netherlands, and Switzerland that top the death toll (Figure 1B) (https://www.worldometers.info/coronavirus/; last accessed May 2, 2020); while Germany and Kuwait, with a lower death toll, constitute most strains with the wild-type 614D at S (Figure 1B).
Introduction: Overall, our observation speculates that the S-D614G strains may be more
Figure: The mutation observed at the S protein of the SARS-COV-2, D614G in white color, may create conformational changes mimicking the open status and facilitate the cleavage domain's exposure to proteases FURIN or TMPRSS2 and could be sufficient to speed up the cleavage.
Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type.
PMID: 32474553
2020
The Indian journal of medical research
Abstract: INTERPRETATION & CONCLUSIONS: SARS-CoV-2 belonging to the A2a type possesses a non-synomymous variant (D614G) that possibly eases the entry of the virus into the lung cells of the host.
Introduction: Although the effect of the D614G mutation is unclear, this mutation is located in the S1-S2 junction near the furin recognition site (R667) for the cleavage of S protein that is required for the entry of the virion into the host cell.
Introduction: Another mutation, A23403G, located in the gene encoding the spike glycoprotein results in an amino acid change (D614G) from aspartic acid to glycine.
Result: The non-synonymous D614G mutation in the Table: D614G
The origin of SARS-CoV-2 in Istanbul: Sequencing findings from the epicenter of the pandemic in Turkey.
Result: Since all three isolates have a D614G variant in spike glycoprotein
Discussion: All three viral isolates carried the D614G marker variant indicating the isolates belong to clade G, which encompasses mostly European countries according to GISAID classification.
Discussion: Clades were named based on variants L84S in ORF8 (S clade), D614G in S gene (G clade), and G251V in ORF3a (V clade).
Discussion: Three isolates in this analysis carried the D614G variant in the S gene, indicating they are all in G clade, which was mostly detected in European countries.
An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations.
Method: Two mutants associated with European Covid-19 patients were constructed using CHARMM-GUI: one is the main strain mutant D614G and the other contains four mutations including Q239K, A831V, D614G and D839Y.
Result: Interestingly, the SARS-CoV-2 spike binding region harbors three residues that have been recently reported to have mutated in new strains from Europe and USA: D614G, A831V and D839Y/N/E).
Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.
Abstract: More importantly, the possible implications of mutation D614G (in SD domain) and G1124V (in S2 subunit) on the structural stability of S protein have also been discussed.
Abstract: Specific mutations, characteristic of the A2a clade, were also detected, which included the P323L in RNA-dependent RNA polymerase and D614G in the Spike glycoprotein.
Discussion: Interestingly, the mutations D614G (in SD domain) is supposed to confer flexibility in the SD domain and the mutation G1124V might impart partial rigidity in the conformation of S2 domain.
Discussion: Notably, the D614G mutation is close to the Furin recogniti
SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East.
Result: In addition to the signature mutation S-D614G annotated by GISAID in clade III, all the Taiwanese genomes shared two ORF1ab mutations C2772T and C14144T (P4715L) (Figure 3E).
Result: To better illustrate phylogenetic clades, we designated and numbered yellow clade as IV harbouring ORF1ab-V378I mutation in this study and three others (blue clade I of ORF8-L84S, gray clade II of ORF3a-G251V, and pink clade III of S-D614G) identified based on previous GISAID annotations of clades S,
SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.
Abstract: Several Spike-protein mutations, including D614G, which has been associated with increased transmission, disrupt otherwise-perfectly-conserved amino acids, and could be novel adaptations to human hosts.
Result: First, we investigated Sarbecovirus conservation of 14 amino acids in the spike protein in which mutations appear to be accumulating in the SARS-CoV-2 population, namely D614G, L5F, L8V/W, H49Y, Y145H, Q239K, V367F, G476S, V483A, V615I/F, A831V,
ViMRT
SARS_CoV_2 mutation literature information.
PMID: 
2020
Pathogens (Basel, Switzerland)
