literature

SARS_CoV_2 mutation literature information.

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model.

PMID: 35273335 2022 Communications biology

Introduction: Experimental data from human lung epithelium and animal models revealed that the D614G substitution increased virus infectivity and transmissibility as compared to an original D614 strain.

Introduction: From January 2020, viruses carrying the spike D614G mutation emerged in several countries.

Introduction: In June, D614G SARS-CoV-2 lineage B.1 became the dominant form of circulating virus worldwide and replaced the initial SARS-CoV-2 strains related to the outbreak in Wuhan, China.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: D614G in the RBM domain has shown to increase the S-protein density on the viral surface, thereby enhancing infectivity.

Introduction: And cilgavimab had lower activity against N501Y+D614G mutants, including B.1.429 (carrying L452R), B.1.617.2 (carrying L452R + T478K) and B.1.351 (carrying K417N + E484K + N501Y).

Introduction: Both P4715L and P323L was observed along with S protein D614G mutation, suggesting a co-evolutionary pattern.

Potential inhibitor for blocking binding between ACE2 and SARS-CoV-2 spike protein with mutations.

PMID: 35279013 2022 Biomedicine & pharmacotherapy

Discussion: Beta variant contains nine mutations in SARS-CoV-2 spike protein: D614G, Delta242-Delta244, R246I, K417N, E484K, N501Y, and A701V.

Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections.

PMID: 35281007 2022 Frontiers in immunology

Discussion: Further follow-up will be needed to confirm whether the specific Nab titer against D614G is maintained or not.

Discussion: The neutralizing titer against D614G significantly decreased in sera of 6-8 months post onset compared to those of 1-3 months post onset ( Figure 3B ).

Discussion: The purpose of this study was to examine the longevity of Nab activity of COVID-19 convalescent sera against D614G, and their neutralizing breadth against B.1.1.7, P.1, and B.1.351.

Discussion: These observations suggested that all participants in this study were likely to be infected with D614G.

Discussion: This reason might be that weak immune-response against SARS-CoV-2 lead to the low Nab titers of 'patients without pneumonia' against

PMID: 35283546 2022 National Academy science letters. National Academy of Sciences, India

Abstract: Their genotyping performed on RNA extracts highlighted the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) sequence variants, all indicative of VOC 202012/01-lineage B.1.1.7, suggesting a common source of infection.

Result: The genotyping performed first by Real-time PCR and then confirmed by direct sequencing proved the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) variants, indicative of VOC 202,012/01-lineage B.

Figure: Sections from the electropherograms showing the 69/70, N501Y, A570D, and D614G (a., b., c., d.) associated with SARS-CoV-2 Alfa Variant B.1.1.7.

Design of SARS-CoV-2 Variant-Specific PCR Assays Considering Regional and Temporal Characteristics.

PMID: 35285246 2022 Applied and environmental microbiology

Result: As a result, for the Alpha variant, we identified nine mutations in the spike gene: S:Delta69/70, S:Delta144, S:N510Y, S:A570D, S:D614G, S:P681H, S:T716I, S:S982A, and S:D1118H.

Result: For the Delta variant, we identified seven mutations: S:T19R, S:Delta156/157, S<

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.

PMID: 35290827 2022 EBioMedicine

Method: The Result: As previously reported, the D614G and Alpha spike variants were less fusogenic than the Delta spike (Figure 2a, b, Figure S2).

Result: We previously reported using this assay that the spike protein of Alpha had the highest affinity to ACE2, followed by Delta and then by D614G.

Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivity.

PMID: 35293847 2022 Emerging microbes & infections

Introduction: L452R, E484Q, D614G, and P681R) are identical or similar to those in other globally circulating SARS-CoV-2 variants.

Introduction: Mutation sites involved in the B.1.617 sub-lineages include T19R, T95I, G142D, E154K, F157del, R158del, L452R, T478K, E484Q, D614G, P681R, D950N, Q1071H, and H1101D.

Introduction: The

RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant.

PMID: 35293849 2022 Emerging microbes & infections

Introduction: Delta variants have a number of characteristic mutations in their spike protein, including single-nucleotide polymorphisms (SNPs) resulting in T19R, R158G, L452R, T478 K, D614G, P681R, and D950N, which are usually chosen as the detection targets of the molecular diagnostics for Delta genotyping.

SARS-CoV-2 spike E156G/Delta157-158 mutations contribute to increased infectivity and immune escape.

PMID: 35296517 2022 Life science alliance

Abstract: We confirmed the presence of E156G/Delta157-158 from cases concurrently screened, in addition to other circulating spike (S1) mutations such as T19R, T95I, L452R, E484Q, and D614G.

Figure: The affinity for the ACE2 receptor was normalized to the D614G-pseudotyped lentiviral particles.

Figure: The fold difference in response to the neutralizing plasma was measured compared to the reference D614G mutant spike

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